Parkinson's disease

1. SEPHIN1 decreases Parkinson's disease in mice.

   Animalsin A53T mice

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

SEPHIN1 →

1. SNCA is associated with Parkinson's disease in humans.

   Review

   Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

2. SNCA is associated with Parkinson's disease in humans.

   Reviewneuron

   Cellular and systemic modifiers of alpha-synuclein proteostasis · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

3. SNCA is associated with Parkinson's disease in humans.

   Review

   Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets · Metabolic brain disease · 28 Sep 2026

SNCA →

1. Parkinson's disease is associated with telomere length in humans.

   Humansblood

   Preliminary insights into whole-blood mitochondrial DNA copy number and telomere length in Parkinson's disease and multiple system atrophy · Journal of neurology · 29 Sep 2026

Telomere length →

1. Parkinson's disease is associated with mitochondrial DNA copy number in humans.

   Humansblood

   Preliminary insights into whole-blood mitochondrial DNA copy number and telomere length in Parkinson's disease and multiple system atrophy · Journal of neurology · 29 Sep 2026

Mitochondrial DNA copy number →

1. Parkinson's disease is associated with triacylglycerols in humans.

   Reviewplasma

   Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes · EMBO reports · 29 Sep 2026

Triacylglycerols →

1. LRRK2 is associated with Parkinson's disease in humans.

   Review

   Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets · Metabolic brain disease · 28 Sep 2026

LRRK2 →

1. PLXDC2 is associated with Parkinson's disease in silico.

   “By constructing the largest-to-date single-cell atlas of the human substantia nigra, we identified a marked upregulation of PLXDC2 in PD microglia.”

   In silicoin PD microgliasubstantia nigra

   Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

PLXDC2 →

1. Mitochondrial dysfunction is associated with Parkinson's disease in humans.

   “Among these, mitochondrial dysfunction recurs across both familial and sporadic PD; however, this broad concept alone cannot explain disease heterogeneity.”

   Reviewacross both familial and sporadic PD

   Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation · International journal of molecular sciences · 11 Sep 2026

Mitochondrial dysfunction →