Dementia
Disease9 papers8 findingsMeSH D003704
- Human trial1
- Humans6
Upstream
1PhenoAge
mediatesin humans1HR 1.0062
1 study
PhenoAge
mediatesin humans1HR 1.0062
PhenoAge mediates dementia in humans (HR 1.0062, 95% CI 1.0002-1.0125).
Humanscombined with KDM-BA for childhood/adolescence smoking association13.67 yearsn = 285,009
Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026
Associations
7Speech age gap
upin humans1
1 study
Speech age gap
upin humans1
Speech age gap is associated with dementia in humans.
Humansn = 2,928
Speech clocks reflect dementia phenotypes and biological aging markers · Science advances · 30 Sep 2026
Childhood and adolescence smoking
upin humans1HR 1.187
1 study
Childhood and adolescence smoking
upin humans1HR 1.187
Childhood and adolescence smoking raises the risk of dementia in humans (HR 1.187, 95% CI 1.106-1.275).
Humans13.67 yearsn = 285,009
Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026
Prenatal tobacco smoke exposure
upin humans1HR 1.094
1 study
Prenatal tobacco smoke exposure
upin humans1HR 1.094
Prenatal tobacco smoke exposure raises the risk of dementia in humans (HR 1.094, 95% CI 1.025-1.168).
Humans13.67 yearsn = 285,009
Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026
SASP Score
upin humans1
1 study
SASP Score
upin humans1
SASP Score predicts dementia in humans.
“The deep learning-based SASP Score was a strong, independent predictor of mortality risk and incident serious, chronic medical conditions (e.g., dementia, COPD, myocardial infarction, stroke).”
Humansblood
A deep learning score for cellular senescence predicts human mortality and disease risk · Aging cell · 26 Sep 2026
Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Mitochondrial dysfunction is associated with dementia.
Reviewin Alzheimer's disease
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies · Frontiers in molecular neuroscience · 15 Sep 2026
Immune Risk Score
upin humans1HR 1.63
1 study
Immune Risk Score
upin humans1HR 1.63
Immune Risk Score raises the risk of dementia in humans (HR = 1.63; 95% CI, 1.28-2.09).
Humansincident CIND/dementiaperipheral bloodn = 4,464
Peripheral immune cell profiles predict cognitive decline in older adults · Age and ageing · 1 Sep 2026
Retinal age gap
upin humans1
1 study
Retinal age gap
upin humans1
Retinal age gap is associated with dementia in humans.
“The resulting retinal age gap, i.e. the difference between predicted and chronological age, is associated with cardiometabolic traits, inflammation, cognitive performance, all-cause mortality, dementia, cancer, and incident cardiovascular disease.”
Humansretinan = 71,343
Retinal imaging model predicts age and reveals sex differences in human aging · Nature communications · 26 Aug 2026
Latest
14Speech clocks reflect dementia phenotypes and biological aging markers
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Science advances · Hernandez H et al.
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.
bioRxiv · Murthygowda S et al.
Lysosomal dysfunction in neurodegenerative disease
Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis
Peripheral immune cell profiles predict cognitive decline in older adults
An immune risk score tracking immunosenescence correlated with markers of neural injury and neuroinflammation rather than classical amyloid or tau pathology.
Age and ageing · Luan H et al.
Biological aging clocks combined with genetics improve dementia risk prediction
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.
Alzheimer's & dementia : the journal of the Alzheimer's Association · Mostafaei S et al.