Glucose
Biomarker1 paper
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14AnimalsMitochondria
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
HumansInflammaging
High metabolic inflammation trajectories predict faster frailty progression in older adults
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Model organismsCellular senescence
Killifish exhibit distinct structural changes and fibrosis during cardiac aging
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.