Frailty index
Biomarker2 papers1 finding
- Humans2
Associations
1Epigenetic alterations
mixedin humans1
1 study
Epigenetic alterations
mixedin humans1
Frailty index is associated with epigenetic alterations in humans (448 differentially methylated regions and 488 differentially variable regions).
Humansbloodn = 1,445
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity · bioRxiv : the preprint server for biology · 25 Sep 2026 · Preprint
Latest
3DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
bioRxiv : the preprint server for biology · Vishnyakova O et al.
High metabolic inflammation trajectories predict faster frailty progression in older adults
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Maturitas · Liu ZY et al.
Machine learning frailty index from healthcare claims predicts mortality and disability
Integrating diagnoses, medications, and procedures into a 63-item tool outperformed an established multimorbidity index in adults aged 50 and older.
Experimental gerontology · Hwang AC et al.