Brain age
Biomarker2 papers1 finding
- Humans2
Associations
1Schizophrenia
upin humans1
1 study
Schizophrenia
upin humans1
Schizophrenia is associated with brain age in humans.
Humansin patients with glymphatic impairmentbrain
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia · bioRxiv · 30 Sep 2026 · Preprint
Latest
19Neural stem cell exhaustion disrupts central nervous system renewal in aging colonial chordates
Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.
bioRxiv : the preprint server for biology · Anselmi C et al.
Aging mouse brains accumulate myelin lipids that drive lysosomal dysfunction
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Cell reports · Sarkar C et al.
Brain cells organize into distinct DNA repair niches during mouse aging
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
bioRxiv : the preprint server for biology · Koshboresh A et al.
Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Research square · Kim H et al.
Human neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
bioRxiv : the preprint server for biology · Caglayan E et al.
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
bioRxiv · Tan X et al.