HDL cholesterol
Biomarker15 papers8 findings
- Human trial1
- Humans8
Interventions
5Time-restricted feeding
downin humans1
1 study
Time-restricted feeding
downin humans1
Time-restricted feeding decreases HDL cholesterol in humans.
Human trialoverweight or obesity≤10-hour eating window7 weeksfemalesn = 131
Interaction between time-restricted eating and high-intensity interval training on cardiometabolic outcomes in women with overweight or obesity: a 2 × 2 factorial randomised controlled trial · The British journal of nutrition · 25 Sep 2026
Aerobic training
upin humans1
1 study
Aerobic training
upin humans1
Aerobic training increases HDL cholesterol in humans.
Review
Comparative efficacy of exercise modalities on cardiometabolic health in older adults: A systematic review and network meta-analysis · Archives of gerontology and geriatrics · 15 Sep 2026
Combined aerobic and resistance exercise
upin humans1
1 study
Combined aerobic and resistance exercise
upin humans1
Combined aerobic and resistance exercise increases HDL cholesterol in humans (Hedges' g = 0.828; 95% CI: 0.051, 1.606).
Reviewin women with breast cancerfemales
The effects of combined aerobic and resistance exercise on metabolic blood biomarkers and quality of life in patients with breast cancer: a systematic review meta-analysis · Frontiers in oncology · 11 Sep 2026
Tirzepatide
upin humans1+11%
1 study
Tirzepatide
upin humans1+11%
Tirzepatide increases HDL cholesterol in humans (+11.3%).
Humanssubcutaneous12 months
Cardiometabolic and atherosclerotic cardiovascular disease outcomes associated with tirzepatide: insights from a 1-year multicenter observational study · Journal of the Endocrine Society · 9 Sep 2026
Mediterranean diet
upin humans1
1 study
Mediterranean diet
upin humans1
Mediterranean diet improves HDL cholesterol in humans.
Review
Lifestyle Medicine and the Science of Cholesterol Reduction: A Systematic Review of Non-medication Approaches Among Adults · Cureus · 30 Aug 2026
Associations
3Mortality
mixedin humans1HR 1.82
1 study
Mortality
mixedin humans1HR 1.82
HDL cholesterol is associated with mortality in humans (HR 1.82 (95% CI 1.45, 2.28) in >99th-100th percentile).
Humansmales
Small HDL particle count is linked to lower mortality · medRxiv · 29 Sep 2026 · Preprint
Six-metabolite signature score
downin humans1
1 study
Six-metabolite signature score
downin humans1
Six-metabolite signature score is associated with HDL cholesterol in humans.
“Within MHO, higher metabolomic score was associated with higher triglycerides, HbA1c, waist-to-hip ratio, lower HDL cholesterol, and greater metabolic and cardiovascular comorbidity burden.”
Humanswithin conventionally defined metabolically healthy obesity
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
Sarcopenic obesity
downin humans1
1 study
Sarcopenic obesity
downin humans1
HDL cholesterol is associated with sarcopenic obesity in humans.
“while higher levels of HDL-C and vitamin D were associated with a lower risk of SO.”
Humans
Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity · Medicine · 1 Sep 2026
Latest
20Mediterranean Diet, Physical Activity, and Metabolic Syndrome in Breast Cancer Survivors on Adjuvant Endocrine Therapy: A Cross-Sectional Study From North Africa
Comparative efficacy of exercise modalities on cardiometabolic health in older adults: A systematic review and network meta-analysis
Non-HDL Cholesterol as a Predictor of Coronary Atherosclerosis in South Asians: A Narrative Review
Chronic kidney disease in type 2 diabetes: Identifying key risk factors from Johor national diabetes registry study
Cardiometabolic and atherosclerotic cardiovascular disease outcomes associated with tirzepatide: insights from a 1-year multicenter observational study
Frequency of Low HDL Cholesterol and the Dose-Dependent Risk of Type 2 Diabetes: A Longitudinal Cohort Study
Small HDL particle count is linked to lower mortality
Top-quartile small HDL particle counts had all-cause mortality hazard ratios of 0.79 in men and 0.77 in women compared with bottom quartiles.Top-quartile small HDL particle counts had all-cause mortality hazard ratios of 0.79 in men and 0.77 in women compared with bottom quartiles.