GLUCOSE-6-PHOSPHATE dehydrogenase deficiency

1. GLUCOSE-6-PHOSPHATE dehydrogenase deficiency decreases HbA1c in humans (4.6 ± 0.5 v 5.5 ± 0.6, P<.001).

   “A1C levels with and without G6PD-D were: 4.6 ± 0.5, (range 3.1 - 5.6) v 5.5 ± 0.6 (range 4.2 - 11.3), P<.001).”

   Humansin African-born Blacksn = 493

   Glucose-6-Phosphate Dehydrogenase Deficiency Masks the Diagnosis of Abnormal Glucose Tolerance by A1C—The Africans in America Study

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on HbA1c

1. GLUCOSE-6-PHOSPHATE dehydrogenase deficiency raises the risk of cardiovascular disease in humans (OR 3.24, 95% CI 2.44-4.30).

   “Multivariate logistic regression analysis confirmed an increased CVD risk in subjects with G6PD deficiency [odd ratio (OR), 3.24; 95% confidence interval (CI) 2.44-4.30]”

   Humansn = 9,604

   The Elderly with Glucose-6-Phosphate Dehydrogenase Deficiency are More Susceptible to Cardiovascular Disease

   Journal of atherosclerosis and thrombosis·10 Sep 2020

More on Cardiovascular disease