Brain age gap

1. Amyloid is associated with brain age gap in silico (83.2% with the leading eigenvector versus a maximal value of 7.7% for any brain region).

   “eigenspectrum of the anatomical covariance matrix explains the different longitudinal effects observed in brain age gap in amyloid positive vs amyloid negative subcohorts more prominently than individual brain regions”

   In silicoin Mild Cognitive Impairment (MCI)brain

   Covariance Eigenspace Provides Latent Attribution of Longitudinal Effects in Brain Age Gap · arXiv · 30 Sep 2026 · Preprint

Amyloid →