Cognitive decline
Disease2 papers
- Animals1
Latest
18Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Huang L et al.
Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice
The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.
Glia · Cimpean A et al.
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Exercise slows epigenetic aging in breast cancer survivors
A randomized trial shows a 12-month workout program slowed DNA methylation clocks and linked with preserved cognitive health.
Journal of the National Cancer Institute · Carlin D et al.
CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
bioRxiv · Harris AS et al.