Animals

Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury

Figure 1. Exacerbation of ischemia–reperfusion (I/R)-induced renal injury in aged mice compared to young mice.Exacerbation of ischemia–reperfusion (I/R)-induced renal injury in aged mice compared to young mice.Oh et al. · CC BY

Biomedicines

Abstract

Background/Objectives : Aging is a major risk factor that exacerbates acute kidney injury (AKI) and subsequent renal fibrosis. However, age-related factors contributing to post-AKI fibrotic remodeling remain underexplored.

Apelin-13
TGF-β signalling
APLN
Renal fibrosis
Acute kidney injury
Mice

The paper

Won-Seok Oh, Sang Gon Lee, H.-T. Kim,

Ji-Hyun Moon, Ah-La Choi, Seung Yun Han, Do Kyung Kim, Nam Seob Lee, Young Gil Jeong,

Geum-Lan Hong

Chungnam National University

Biomedicines · 10 Sep 2026 · CC BY

doi.org/10.3390/biomedicines14092033 PubMed 42792775

Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury

Abstract

The paper

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Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury

Abstract

The paper

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