Brain agingAnimals60 rats8 weeks

High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence

Fig. 1. Experimental timeline of the HIIT protocol in a β-amyloid-induced Alzheimer’s model.
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Fig. 1. Experimental timeline of the HIIT protocol in a β-amyloid-induced Alzheimer’s model.Experimental timeline of the HIIT protocol in a β-amyloid-induced Alzheimer’s model.Godinho et al. · CC BY

Experimental Brain Research

Abstract

High-intensity interval training (HIIT) has emerged as a promising non-pharmacological strategy for neuroprotection, although its molecular effects in Alzheimer's disease (AD) remain unclear.

The paper

Universidade Estadual do Ceará

Experimental Brain Research · 25 Sep 2026 · CC BY

doi.org/10.1007/s00221-026-07397-5PubMed 42789105

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