Animals

Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats

Figure 1. Estrogen mitigates bone density loss and improves bone microarchitecture in OVX rats.
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Figure 1. Estrogen mitigates bone density loss and improves bone microarchitecture in OVX rats.Estrogen mitigates bone density loss and improves bone microarchitecture in OVX rats.Wang et al. · CC BY

Biology

Abstract

Postmenopausal osteoporosis (PMOP) is characterized by excessive bone resorption caused by increased osteoclast activity. Estrogen remains an effective therapeutic option for preventing bone loss; however, its regulatory effects on osteoclast cytoskeletal remodeling have not been fully clarified.

The paper

China Academy of Chinese Medical Sciences

Biology · 9 Sep 2026 · CC BY

doi.org/10.3390/biology15181585PubMed 42792530

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