Biomarkers

Sun 27 Sep3 papers

medRxivHumansPreprint

Voice taxonomy detects cognitive decline and Alzheimer markers

In 1,479 participants across three cohorts, a new voice taxonomy differentiated mild cognitive impairment with an effect size of d = −0.39 and tracked…In 1,479 participants across three cohorts, a new voice taxonomy differentiated mild cognitive impairment with an effect size of d = −0.39 and tracked cognitive change. In 1,479 human participants across three cohorts, researchers evaluated a new speech framework to detect cognitive…

Speech-processing and feature-extraction pipeline.
Mild cognitive impairment
bioRxivHumansPreprint

Auditory brainstem signals track age-related hearing deficits

In normal-hearing listeners, auditory brainstem responses and behavioral detection thresholds revealed that declining Wave V amplitudes correlated…In normal-hearing listeners, auditory brainstem responses and behavioral detection thresholds revealed that declining Wave V amplitudes correlated with poorer temporal processing at higher sound levels.

Ear
medRxivHumansPreprint

Remote digital test flags cognitive impairment in older adults

In a study of 2,249 adults, a remote test discriminated cognitive impairment with an AUC of 0.89, rising to 0.95 when confirmed by amyloid biomarkers.In a study of 2,249 adults, a remote test discriminated cognitive impairment with an AUC of 0.89, rising to 0.95 when confirmed by amyloid biomarkers. In a preprint study of 2,249 older human adults with an average age of 70, researchers evaluated the Mayo Test Drive, a remote…

Model performance for predicting clinical diagnosis: cognitively unimpaired (n=2131) versus cognitively impaired (n=118 with MCI or mild dementia).
Mini-Mental State Examination

Sat 26 Sep98 papers

GenesHumans

Blood methylation clocks capture two distinct biological domains of aging

Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors…Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors, and lifestyle exposures. In human participants from the Family and Community Health Study, researchers evaluated whether blood-based DNA…

Kernel-density distributions of the six standardized blood DNAm scores.
PhenoAge
Aging CellHumans

Deep-learning SASP score predicts mortality and disease

Trained on UK Biobank proteomic data, a deep-learning senescence score independently predicted mortality risk and shifted during an 18-month exercise…Trained on UK Biobank proteomic data, a deep-learning senescence score independently predicted mortality risk and shifted during an 18-month exercise trial. In human data from the UK Biobank Pharma Proteomics Project, researchers developed a composite score to track systemic cellular…

Dense blood cells and granules under vital organs above standing figures contrast with a sparser cluster above active figures exercising.
European Journal of Heart FailureHumans

Proteomic multi-organ aging accelerates before adverse events in heart failure patients

Organ age gaps for the kidney, lung, and immune system predicted patient outcomes independently of standard clinical biomarkers.Organ age gaps for the kidney, lung, and immune system predicted patient outcomes independently of standard clinical biomarkers. In a study of human participants across two heart failure cohorts, researchers tracked proteomic organ age gaps over time.

A damaged heart crumbling into red specks sits below healthy and deteriorating pairs of kidneys, lungs, and immune cells.
NT-proBNP
Nature CommunicationsHumans

Retinal imaging model predicts age and reveals sex differences in human aging

The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants. Researchers analyzed retinal fundus images from 71,343 human participants in the UK Biobank.

Two retinal fundus scans above two hearts, one paired with a cluster of fat cells and the other with a branching vascular network.
Metabolic syndrome
Experimental GerontologyHumans

Machine learning frailty index from healthcare claims predicts mortality and disability

Integrating diagnoses, medications, and procedures into a 63-item tool outperformed an established multimorbidity index in adults aged 50 and older.Integrating diagnoses, medications, and procedures into a 63-item tool outperformed an established multimorbidity index in adults aged 50 and older. Researchers evaluated middle-aged and older adults aged 50 and older by linking the Taiwan Longitudinal Study on Aging with the National…

Figure 1
Frailty index