Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity
Abstract · CC BY
The "unexplained failure" of rotator cuff repair is multifactorial, but its structural endpoint is anatomically consistent, i.e., the failure of the tendon-to-bone interface (enthesis) to heal.
- Altered intercellular communication
- Cellular senescence
- Epigenetic alterations
- Stem cell exhaustion
- DNA methylation
- Senescence-associated secretory phenotype (SASP)
- Rotator cuff tear
- DNA methylation epigenetic clock
- Epigenetic age acceleration
- Homo sapiens
The paper
Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity
Yoon JP, Park SJ, Kim DH et al.
Biomedicines · 2 Sep 2026