For atherosclerotic cardiovascular disease, polygenic risk expanded the clinically identified high-risk subgroup by 40%, revealing patients with…For atherosclerotic cardiovascular disease, polygenic risk expanded the clinically identified high-risk subgroup by 40%, revealing patients with 4.9-fold higher incidence than those remaining low-risk.
In a study of 84 older adults, a virtual reality Trail Making Test separated people with mild cognitive impairment from controls more effectively than…In a study of 84 older adults, a virtual reality Trail Making Test separated people with mild cognitive impairment from controls more effectively than paper tests. In a case–control preprint, 84 adults aged 60 to 89 years—42 with clinically diagnosed mild cognitive impairment and 42…
A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified…A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified key structural markers of aging.
Higher ln(WHR) was associated with sarcopenia in NHANES adults with an adjusted odds ratio of 2.50 and in KNHANES adults at 1.85.Higher ln(WHR) was associated with sarcopenia in NHANES adults with an adjusted odds ratio of 2.50 and in KNHANES adults at 1.85. Researchers analyzed data from 10,131 US adults in NHANES (2011–2018) and 7,872 Korean adults in KNHANES (2010–2011) to assess whether the white blood cell to…
Participants in the highest quartile of allostatic load had over double the cancer risk compared to the lowest quartile, showing an odds ratio of…Participants in the highest quartile of allostatic load had over double the cancer risk compared to the lowest quartile, showing an odds ratio of 2.24. In a nested case-control study of 955 incident cancer cases and 955 matched controls from the European Prospective Investigation into…
Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and…Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and cardiovascular mortality. In a study of 11,910 NHANES participants and 865 hospital patients, researchers evaluated nocturia across stages of…
In 89 adults, high- and moderate-inflammatory endotypes had adjusted odds ratios of 17.2 and 7.1 for COPD high-risk status versus a low-inflammatory…In 89 adults, high- and moderate-inflammatory endotypes had adjusted odds ratios of 17.2 and 7.1 for COPD high-risk status versus a low-inflammatory group. In a study of human adults, researchers investigated age-associated immune biomarkers to identify distinct inflammatory profiles…
In 551 older patients, intrinsic capacity showed a stronger link to post-rehabilitation walking outcomes (β = 0.571) than the frailty index (β =…In 551 older patients, intrinsic capacity showed a stronger link to post-rehabilitation walking outcomes (β = 0.571) than the frailty index (β = -0.281). The observational study evaluated 551 older adults aged 65 and older who were hospitalized for exercise-based cardiac rehabilitation in…
In about 155,000 PLCO cohort participants, adding sex-specific clinical history to models improved disease prediction and calibration, especially at…In about 155,000 PLCO cohort participants, adding sex-specific clinical history to models improved disease prediction and calibration, especially at higher multimorbidity burdens.
In 7,362 older patients hospitalized with heart failure, combining physical performance scores with calf circumference stratified one-year mortality…In 7,362 older patients hospitalized with heart failure, combining physical performance scores with calf circumference stratified one-year mortality risk across cohorts. In a multicenter study of 7,362 Japanese patients aged 65 and older hospitalized with heart failure, researchers…
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan. Researchers profiled plasma and cerebrospinal fluid from 66 rhesus macaques across adult, pre-geriatric, and geriatric ages using targeted proteomics.
In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change…In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change over time. In a study of 139 adults aged 25 to 65, researchers investigated how DNA methylation measures of biological age relate to specific…
In older Australians, epigenetic smoking scores explained up to 50% of pack-year variance, with mCigarette carrying a 2.18-fold higher lung cancer…In older Australians, epigenetic smoking scores explained up to 50% of pack-year variance, with mCigarette carrying a 2.18-fold higher lung cancer risk per standard deviation.
A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables…A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables alone. In 13,215 adults with obesity from the UK Biobank, researchers evaluated whether circulating metabolites could distinguish metabolically…
Prediabetic adults in the highest CTI quartile had an increased osteoarthritis risk (hazard ratio 1.376) over nine years of follow-up.Prediabetic adults in the highest CTI quartile had an increased osteoarthritis risk (hazard ratio 1.376) over nine years of follow-up. In 3,043 middle-aged and older adults with prediabetes from the China Health and Retirement Longitudinal Study, researchers evaluated the link between the…
