LDL-C

1. Corn-derived dietary fibers decrease LDL-C in humans (WMD: -8.82 mg/dL).

   Reviewsupplementation in adults

   Effects of corn-derived dietary fibers on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials · Diabetes research and clinical practice · 3 Oct 2026

Corn-derived dietary fibers →

1. Sprint interval training decreases LDL-C in humans.

   Reviewversus no-exercise control

   Effects of sprint interval training on markers of metabolic health: A three-level meta-analysis of randomised controlled trials · Journal of sports sciences · 1 Oct 2026

Sprint interval training →

1. Bempedoic acid + ezetimibe decreases LDL-C in humans (-36.90% (95% CI: -44.65 to -29.15)).

   Reviewdyslipidaemia

   Efficacy and Safety of Oral Non-Statin Lipid-Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta-Analysis · Endocrinology, diabetes & metabolism · 1 Oct 2026

Bempedoic acid + ezetimibe →

1. Obicetrapib + ezetimibe decreases LDL-C in humans (-49.15% (95% CI: -59.42 to -38.89)).

   Reviewdyslipidaemia10 mg plus 10 mg

   Efficacy and Safety of Oral Non-Statin Lipid-Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta-Analysis · Endocrinology, diabetes & metabolism · 1 Oct 2026

Obicetrapib + ezetimibe →

1. Lipid-lowering therapy improves LDL-C in humans.

   Humansin high and very high cardiovascular risk patients

   Mexican Registry of Dyslipidemias of the Mexican Institute of Social Security: Lipid Profiles in Patients at High and Very High Cardiovascular Risk · Archives of medical research · 28 Sep 2026

Lipid-lowering therapy →

1. Bempedoic acid decreases LDL-C in humans.

   Reviewin high- and very-high-risk individuals unable or unwilling to take statins

   Bempedoic Acid: From Guidelines to the Real World · Journal of lipid and atherosclerosis · 4 May 2026

Bempedoic acid →

1. LDL-C raises the risk of atherosclerotic cardiovascular disease in humans (sHR 1.69, 95% CI 1.35-2.12).

   Humans22.7 yearsn = 10,550

   Martin-Hopkins LDL equation best predicts cardiovascular risk · Circulation. Population health and outcomes · 30 Sep 2026

2. LDL-C lowers the risk of atherosclerotic cardiovascular disease in humans.

   Reviewin ASCVD

   Optimal LDL-C Levels for Ischemic Stroke Prevention: A Neurologist's Perspective · Journal of lipid and atherosclerosis · 27 May 2026

Atherosclerotic cardiovascular disease →

1. MTNR1B is associated with LDL-C in humans.

   Humansin both seasonsn = 63

   MTNR1B rs10830963 Genotype Amplifies Lipid Susceptibility to Poor Circadian Light Hygiene · Preprints.org · 29 Sep 2026 · Preprint

MTNR1B →

1. LDL-C lowers the risk of ischemic stroke in humans.

   Reviewin patients with atherosclerotic stroke

   Optimal LDL-C Levels for Ischemic Stroke Prevention: A Neurologist's Perspective · Journal of lipid and atherosclerosis · 27 May 2026

Ischemic stroke →