Zoledronic acid
InterventionApproved 20014 papers1 findingPubChem 68740ChEBI 46557
- Human trial1
Associations
1Vertebral fracture
downin humans1
1 study
Vertebral fracture
downin humans1
Zoledronic acid lowers the risk of vertebral fracture in humans.
Reviewin men
Bone health in older men · Maturitas · 10 Sep 2026
Trials
246Approved
20 Mar 2001 · Cancer, Fractures, Bone
20 Aug 2001 · Discontinued
22 Feb 2002
15 Apr 2005 · Osteoporosis, Osteitis Deformans, Osteoporosis, Postmenopausal, Paget's Disease of the Bone, hip fracture, trauma
16 Apr 2007 · Osteoporosis, Osteoporosis, Postmenopausal, glucocorticoid-induced osteoporosis
17 Aug 2007
All 16Fewer
20 Apr 2012 · Withdrawn · Fractures, Bone
3 Aug 2012 · Withdrawn · Fractures, Bone, Cancer
EMA · Zoledronic acid Teva Pharma
15 Aug 2012 · Withdrawn · Osteoporosis, Osteitis Deformans, Osteoporosis, Postmenopausal, hip fracture, trauma
16 Aug 2012 · Fractures, Bone, Cancer
23 Aug 2012 · Fractures, Bone
19 Nov 2012 · Withdrawn · Hypercalcemia, Osteoporosis, Paget's Disease of the Bone, hip fracture, trauma
2 Aug 2013 · Multiple Myeloma, Hypercalcemia of Malignancy, Prostate Cancer, bone metastases
16 Jan 2014 · Hypercalcemia, Fractures, Bone, Cancer
EMA · Zoledronic acid Teva Generics
27 Mar 2014 · Withdrawn · Osteoporosis, Osteitis Deformans, Paget's Disease of the Bone, hip fracture, trauma
28 Dec 2015 · Discontinued
Repurposing
Phase 4 · Completed · 3 trials
Phase 3 · Status unknown · 2 trials
Phase 3 · Terminated · 1 trial
Phase 4 · Results posted · 2 trials
Phase 4 · Completed · 1 trial
Phase 4 · Status unknown · 1 trial
All 34Fewer
Phase 3 · Status unknown · 1 trial
Phase 4 · Results posted · 4 trials
Phase 4 · Completed · 6 trials
Phase 4 · Completed · 9 trials
Phase 3 · Results posted · 2 trials
Phase 4 · Completed · 1 trial
Phase 4 · Results posted · 1 trial
Phase 4 · Completed · 1 trial
Phase 4 · Completed · 6 trials
Phase 3 · Completed · 5 trials
Phase 4 · Completed · 4 trials
Phase 3 · Results posted · 2 trials
Phase 3 · Results posted · 2 trials
Phase 3 · Completed · 1 trial
Phase 3 · Active, not recruiting · 7 trials
Phase 3 · Completed · 1 trial
Phase 2 · Results posted · 3 trials
Phase 2 · Results posted · 2 trials
Phase 2 · Results posted · 1 trial
Phase 2 · Results posted · 1 trial
Phase 2 · Results posted · 1 trial
Phase 2 · Results posted · 1 trial
Central nervous system disease
Phase 2 · Results posted · 1 trial
Phase 2 · Completed · 1 trial
Phase 1/2 · Recruiting · 2 trials
Hematopoietic stem cell transplantation
Phase 1 · Completed · 2 trials
Phase 1/2 · Recruiting · 1 trial
Phase 1 · Terminated · 1 trial
In trials
Breast Neoplasms
Phase 4 · Results posted · 49 trials
Prostatic Neoplasms
Phase 4 · Completed · 41 trials
Metabolic bone disease
Phase 4 · Results posted · 23 trials
Neoplasm Metastasis
Phase 4 · Results posted · 18 trials
Non-Small-Cell Lung Carcinoma
Phase 4 · Completed · 9 trials
Lung Neoplasms
Phase 4 · Completed · 8 trials
All 23Fewer
Bone Neoplasms
Phase 4 · Completed · 2 trials
Malignant Pleural Effusion
Phase 4 · Completed · 2 trials
Thalassemia
Phase 4 · Completed · 2 trials
Plasma Cell Neoplasms
Phase 3 · Results posted · 5 trials
Sarcoma
Phase 3 · Active, not recruiting · 3 trials
Ewing sarcoma
Phase 3 · Completed · 2 trials
Giant Cell Tumor of Bone
Phase 3 · Recruiting · 2 trials
Humoral Hypercalcemia Of Malignancy
Phase 3 · Completed · 2 trials
Small cell lung carcinoma
Phase 3 · Completed · 2 trials
Triple Negative Breast Neoplasms
Phase 3 · Status unknown · 2 trials
Beta thalassemia
Phase 2/3 · Status unknown · 1 trial
Kidney Neoplasms
Phase 2 · Results posted · 3 trials
Ovarian Neoplasms
Phase 2 · Results posted · 2 trials
Uterine Cervical Neoplasms
Phase 2 · Terminated · 2 trials
Neuroblastoma
Phase 1/2 · Recruiting · 6 trials
Rhabdomyosarcoma
Phase 1/2 · Recruiting · 2 trials
Stomach neoplasm
Phase 1/2 · Recruiting · 1 trial
Stopped
NCT00333229 · Terminated · Breast Neoplasms
Due to rare patient population, planned number of patients could not be recruited in a reasonable timeframe. Recruitment was stopped prematurely.
NCT00582790 · Terminated · Kidney Neoplasms
slow accrual
NCT00966992 · Terminated · Uterine Cervical Neoplasms
Lack of enrollment
NCT00278434 · Terminated · Precancerous condition
Accrual was insufficient to meet study endpoints
Trial sponsors
Company72 trialsPhase 428,486 people
Company2 trialsPhase 33,839 people
Company1 trialPhase 31,360 people
Company1 trialPhase 3487 people
Company1 trialPhase 3190 people
Company1 trialPhase 2150 people
Company1 trialPhase 2139 people
Company1 trialPhase 2112 people