Elective spinal reconstructive surgery

1. Elective spinal reconstructive surgery increases senescence-associated secretory phenotype (SASP) in humans.

   “Senescence-associated secretory phenotype proteins were higher in older patients at baseline and further elevated during and after surgery.”

   Human trialelective spinal reconstructive surgeryplasma

   Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Response

   Journal of the American College of Surgeons·Dec 14, 2023

More on Senescence-associated secretory phenotype (SASP)

1. Elective spinal reconstructive surgery decreases natural killer cells in humans.

   “natural killer cells were markedly activated after polytrauma, they were suppressed after surgery, especially in older patients”

   Human trialelective spinal reconstructive surgeryblood

   Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Response

   Journal of the American College of Surgeons·Dec 14, 2023

More on Natural killer cells

1. Elective spinal reconstructive surgery increases inflammation in humans.

   “Older patient's cluster of differentiation 14 monocytes displayed higher inflammation and less major histocompatibility complex-class 2 suppression”

   Human trialelective spinal reconstructive surgeryblood

   Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Response

   Journal of the American College of Surgeons·Dec 14, 2023

More on Inflammation