Tumorigenesis
Disease2 papers2 findings
- Animals1
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2Senescence-associated secretory phenotype (SASP)
downin reviews1
1 study
Senescence-associated secretory phenotype (SASP)
downin reviews1
Senescence-associated secretory phenotype (SASP) decreases tumorigenesis.
Reviewtransient SASP
A Review of Senescence-Associated Secretory Phenotype-Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy · Cancer reports (Hoboken, N.J.) · 1 Sep 2026
CTNNB1
upin mice1
1 study
CTNNB1
upin mice1
CTNNB1 increases tumorigenesis in mice.
Animalsduring chronic injury or agingliver
Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity · Nature communications · 10 Aug 2026
Funding
National Cancer InstituteUS$1.3mNational Institute on Alcohol Abuse and AlcoholismUS$2.8m4 grants since 2019
Defining the Function of Age-Related Epimutation in Intestinal Tumorigenesis
National Cancer InstituteBaylor College of MedicineUS$386.2k2019–2030
National Institute on Alcohol Abuse and AlcoholismUniv of North Carolina Chapel HillUS$2.8m2026–2030
Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis
National Cancer InstituteUniv of Massachusetts Med Sch WorcesterUS$437k2024–2029
Lactation on Breast Tumorigenesis
National Cancer InstituteBaylor College of MedicineUS$523.3k2023–2028
Latest
22Detection of cancer epigenetic alterations in a pilot cohort of workers exposed to TiO₂
Three-protein combination eased chronic liver disease in rats
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.
SASP factors drive growth of altered cancer cells in culture
Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to…Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to promote proliferation.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
Partial Y chromosome loss alters transcription in cancer cells
Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to…Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to transcriptional changes.