Levocarnitine
- 4 independent labs in 4 countries
- 1 finding against
- Funders: Japan Science and Technology Agency and 5 more
- Animals4
- Cells1
Outcomes
8Lifespan
upin mice1no changein rats1
2 studies
Lifespan
upin mice1no changein rats1
Levocarnitine has no effect on lifespan in rats.
“L-CAR had no negative effects on growth, kidney function at 50 wk, and survival at 101 wk.”
Animals
Pediatric research1 Feb 2011
Levocarnitine extends lifespan in mice (log-rank P=0.0001).
“delayed deterioration of motor activity, and extended life span (log-rank P=0.0001) in transgenic mice carrying a human SOD1 gene with a G93A mutation”
Animalsprior to disease onsetoral administration
Brain research17 Jan 2006
Oxidative stress and ROS signalling
downin rats1
1 study
Oxidative stress and ROS signalling
downin rats1
Levocarnitine decreases oxidative stress and ROS signalling in rats.
“Total oxidant capacity levels decreased and total antioxidant capacity levels increased in the hippocampus of aged rats treated with L-carnitine.”
Animalsnatural agingoral gavagehippocampus50 mg/kg/day7 monthsmalesn = 60
Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms
Experimental brain research20 Jun 2025
Learning performance
upin rats1
1 study
Learning performance
upin rats1
Levocarnitine improves learning performance in rats.
“L-carnitine administration increased learning performance.”
Animalsnatural agingoral gavage50 mg/kg/day7 monthsmalesn = 60
Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms
Experimental brain research20 Jun 2025
Cellular senescence
downin rat cells1
1 study
Cellular senescence
downin rat cells1
Levocarnitine decreases cellular senescence in rat cells.
“0.2 mM LC supplementation could significantly decrease the population doubling time and aging of rADSCs.”
Cellsin cultured rADSCs0.2 mM
L-carnitine significantly decreased aging of rat adipose tissue-derived mesenchymal stem cells
Veterinary research communications10 Dec 2016
Cell proliferation
upin rat cells1
1 study
Cell proliferation
upin rat cells1
Levocarnitine increases cell proliferation in rat cells.
“The results showed significant proliferation of rADSCs 48 h after treatment with concentrations of 0.2 mM LC.”
Cellsin cultured rADSCs0.2 mM48 h
L-carnitine significantly decreased aging of rat adipose tissue-derived mesenchymal stem cells
Veterinary research communications10 Dec 2016
Food intake
downin rats1
1 study
Food intake
downin rats1
Levocarnitine decreases food intake in rats (one-third less).
“A serendipitous finding was that L-CAR treatment caused one-third less food intake; however, these rats maintained normal body weight.”
Animals
Pediatric research1 Feb 2011
Motor activity deterioration
downin mice1
1 study
Motor activity deterioration
downin mice1
Levocarnitine decreases motor activity deterioration in mice.
“delayed deterioration of motor activity”
Animalsprior to disease onsetoral administration
Brain research17 Jan 2006
Onset of signs of disease
downin mice1
1 study
Onset of signs of disease
downin mice1
Levocarnitine decreases onset of signs of disease in mice (log-rank P=0.0008).
“oral administration of L-carnitine prior to disease onset significantly delayed the onset of signs of disease (log-rank P=0.0008)”
Animalsprior to disease onsetoral administration
Brain research17 Jan 2006