Glynac

1. Glynac improves cognitive function in humans.

   “present results from a human trial showing improvements in cognition, glutathione deficiency, and novel defects in metabolism and mitochondria.”

   Reviewin age-related cognitive decline

   MITOCHONDRIA, METABOLISM, AND GLUTATHIONE AS MEDIATORS OF COGNITIVE DECLINE IN AGING AND ALZHEIMER’S DISEASE · GSA 2024 abstract · 31 Dec 2024

2. Glynac improves cognitive function in mice.

   “present data on successfully reversing these defects with GlyNAC supplementation.”

   Reviewin old micebrain

   MITOCHONDRIA, METABOLISM, AND GLUTATHIONE AS MEDIATORS OF COGNITIVE DECLINE IN AGING AND ALZHEIMER’S DISEASE · GSA 2024 abstract · 31 Dec 2024

3. Glynac improves cognitive function in mice.

   “After 8-weeks of supplementing GlyNAC (combination of glutathione precursors glycine and N-acetylcysteine), all defects improved/corrected in the brains of OM, and cognitive performance improved significantly.”

   Animalsaged micecombination of glutathione precursors glycine and N-acetylcysteinebrain8-weeks

   BRAIN GLUTATHIONE, MITOCHONDRIA, GLUCOSE METABOLISM, AND COGNITION IN AGED MICE: IMPACT OF GLYNAC SUPPLEMENTATION · GSA 2024 abstract · 31 Dec 2024

4. Glynac improves cognitive function in mice.

   “cognitive performance improved significantly.”

   Animalsin old mice (90-weeks)8 weeks

   BRAIN GLUTATHIONE, MITOCHONDRIA, GLUCOSE METABOLISM, AND COGNITION IN AGED MICE: IMPACT OF GLYNAC SUPPLEMENTATION · GSA 2024 abstract · 31 Dec 2024

1. Glynac increases glutathione in mice.

   “all of these defects improved/corrected in the brains of OM”

   Animalsin old mice (90-weeks)brain8 weeks

   BRAIN GLUTATHIONE, MITOCHONDRIA, GLUCOSE METABOLISM, AND COGNITION IN AGED MICE: IMPACT OF GLYNAC SUPPLEMENTATION · GSA 2024 abstract · 31 Dec 2024

2. Glynac improves glutathione in humans.

   “GlyNAC (and not placebo) supplementation in OA improved/corrected these defects.”

   Human trialolder adults16-weeksn = 24

   GLYNAC SUPPLEMENTATION IN OLDER ADULTS IMPROVES GLUTATHIONE, MITOCHONDRIA, AGING HALLMARKS, AND FUNCTION · GSA 2024 abstract · 31 Dec 2024

Glutathione →

1. Glynac has no effect on fibrillar collagen in mice.

   “no significant change in fibrillar collagen was detected in the hearts of GlyNAC-fed old males.”

   Animalsdietary supplementationheart3 monthsmales

   GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES · GSA 2024 abstract · 31 Dec 2024

Fibrillar collagen →

1. Glynac increases FMOD in mice.

   “MS analysis determined that GlyNAC increased fibromodulin (Fmod) expression, which can inhibit collagen fibril formation.”

   Animalsdietary supplementationheart3 monthsmales

   GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES · GSA 2024 abstract · 31 Dec 2024

FMOD →

1. Glynac increases NDUFB8 in mice.

   “a GlyNAC-supplemented diet led to an increase of Ndufb8 expression (a subunit of the mitochondrial respiratory chain complex)”

   Animalsdietary supplementationheart3 months

   GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES · GSA 2024 abstract · 31 Dec 2024

NDUFB8 →

1. Glynac improves exercise performance in mice.

   “supplementing a diet with GSH precursors (termed GlyNAC) for 3 months, improved cardiac diastolic function (measured longitudinally) and exercise performance in males.”

   Animalsdietary supplementation3 monthsmales

   GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES · GSA 2024 abstract · 31 Dec 2024

1. Glynac improves cardiac diastolic function in mice.

   “supplementing a diet with GSH precursors (termed GlyNAC) for 3 months, improved cardiac diastolic function (measured longitudinally) and exercise performance in males.”

   Animalsdietary supplementationheart3 monthsmales

   GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES · GSA 2024 abstract · 31 Dec 2024

Cardiac diastolic function →

1. Glynac improves oxidative phosphorylation in mice.

   “After 8-weeks of supplementing GlyNAC (combination of glutathione precursors glycine and N-acetylcysteine), all defects improved/corrected in the brains of OM”

   Animalsaged micecombination of glutathione precursors glycine and N-acetylcysteinebrain8-weeks

   BRAIN GLUTATHIONE, MITOCHONDRIA, GLUCOSE METABOLISM, AND COGNITION IN AGED MICE: IMPACT OF GLYNAC SUPPLEMENTATION · GSA 2024 abstract · 31 Dec 2024

Oxidative phosphorylation →

1. Glynac improves mitochondrial respiration in mice.

   “all of these defects improved/corrected in the brains of OM”

   Animalsin old mice (90-weeks)brain8 weeks

   BRAIN GLUTATHIONE, MITOCHONDRIA, GLUCOSE METABOLISM, AND COGNITION IN AGED MICE: IMPACT OF GLYNAC SUPPLEMENTATION · GSA 2024 abstract · 31 Dec 2024

1. Glynac decreases insulin resistance in humans.

   “GlyNAC (and not placebo) supplementation in OA improved/corrected these defects.”

   Human trialolder adults16-weeksn = 24

   GLYNAC SUPPLEMENTATION IN OLDER ADULTS IMPROVES GLUTATHIONE, MITOCHONDRIA, AGING HALLMARKS, AND FUNCTION · GSA 2024 abstract · 31 Dec 2024

Insulin resistance →