Sulfur amino acid restriction

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals2

Outcomes

5

ME1

upin rats1

1 study

Sulfur amino acid restriction increases ME1 in rats.
“SAAR increased the cytosolic malic enzyme (ME1) without affecting mitochondrial ME3”
Animals0.17% methioninelivermales
Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats
Redox report : communications in free radical research10 Oct 2026

G6PD

downin rats1

1 study

Sulfur amino acid restriction decreases G6PD in rats.
“lowered glucose-6-phosphate dehydrogenase levels, indicating a pro-oxidant milieu”
Animalscompared with CR0.17% methioninelivermales
Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats
Redox report : communications in free radical research10 Oct 2026

GSSG:tGSH

upin rats1

1 study

Sulfur amino acid restriction increases GSSG:tGSH in rats.
“increased GSSG:tGSH, protein-bound GSH:tGSH, and lowered glucose-6-phosphate dehydrogenase levels”
Animalscompared with CR0.17% methioninelivermales
Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats
Redox report : communications in free radical research10 Oct 2026

More on GSSG:tGSH

tGSH

downin rats1

1 study

Sulfur amino acid restriction decreases tGSH in rats.
“Compared with CR, SAAR decreased the hepatic total free glutathione (tGSH)”
Animalscompared with CR0.17% methioninelivermales
Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats
Redox report : communications in free radical research10 Oct 2026

Bone mineral density

downin mice1

1 study

Sulfur amino acid restriction decreases bone mineral density in mice.
“femurs and tibiae of SAAR mice had lower trabecular and cortical BMD, fewer osteoblasts, reduced biomechanical strength, and more marrow adipocytes than in CD mice”
Animalsin high-fat diet-fed male micemales
D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice
Aging2 Mar 2026

More on Bone mineral density

Latest

3 in 12 months

Redox Report8 h

Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats

Experiments in ratsDietary restriction

Experimental Physiology25 Mar

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

ReviewAcute kidney injury

Aging6 Mar

D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice

Experiments in miceObesity