Essential hypertension

1. Essential hypertension is associated with anti-NR2 antibody in humans (1.6 [1.15; 2.62] vs. 1.33 [1.02; 1.84] ng/mL, p = 0.03).

   “NR2 antibody levels were higher in HTN (1.6 [1.15; 2.62] vs. 1.33 [1.02; 1.84] ng/mL; p = 0.03).”

   Humansin patients with essential HTN and controlsn = 175

   Arterial Stiffness and Anti-NR2/GluN2 Autoantibodies to N-Methyl-D-Aspartate Receptors as Markers of Vascular Aging and Cognitive Impairment in Arterial Hypertension · Life (Basel, Switzerland) · 26 Aug 2026

anti-NR2 antibody →

1. Essential hypertension raises the risk of cognitive impairment in humans (52.3% vs. 27.7% (MoCA), 48.7% vs. 28.3% (MMSE)).

   “Cognitive impairment was more frequent in hypertensive patients by both MoCA (52.3% vs. 27.7%; p = 0.003) and MMSE (48.7% vs. 28.3%; p = 0.01).”

   Humansin patients with essential HTN and controlsn = 175

   Arterial Stiffness and Anti-NR2/GluN2 Autoantibodies to N-Methyl-D-Aspartate Receptors as Markers of Vascular Aging and Cognitive Impairment in Arterial Hypertension · Life (Basel, Switzerland) · 26 Aug 2026

Cognitive impairment →

1. Essential hypertension is associated with CAVI in humans (8.3 [7.3; 9.4] vs. 7.3 [6.9; 7.9], p = 0.001).

   “Patients with HTN had higher CAVI values than controls (8.3 [7.3; 9.4] vs. 7.3 [6.9; 7.9]; p = 0.001).”

   Humansin patients with essential HTN and controlsn = 175

   Arterial Stiffness and Anti-NR2/GluN2 Autoantibodies to N-Methyl-D-Aspartate Receptors as Markers of Vascular Aging and Cognitive Impairment in Arterial Hypertension · Life (Basel, Switzerland) · 26 Aug 2026

CAVI →