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Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling

Biochemical and Biophysical Research Communications

  • Mitochondria-targeted esculetin
  • SIRT1
  • APOE
  • Cardiac remodeling
  • Cardiac hypertrophy
  • Mice

The paper

Chempon H, Pulipaka S, Shaikh A et al.

Biochemical and Biophysical Research Communications · 10 Sep 2026

doi.org/10.1016/j.bbrc.2026.154568PubMed 42727477

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