Lithocholic acid

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Key Research and Development Program of China

Animals1

Outcomes

Healthspan

upin flies1upin worms1

1 study

Lithocholic acid improves healthspan in flies.
“In nematodes and flies, LCA depends on the TULP3 homologues tub-1 and ktub, respectively, to activate AMPK and extend lifespan and healthspan.”
Model organismsDependent on ktub
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Nature18 Dec 2024
Lithocholic acid improves healthspan in worms.
“In nematodes and flies, LCA depends on the TULP3 homologues tub-1 and ktub, respectively, to activate AMPK and extend lifespan and healthspan.”
Model organismsDependent on tub-1
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Nature18 Dec 2024

Lifespan

upin flies1upin worms1

1 study

Lithocholic acid extends lifespan in flies.
“In nematodes and flies, LCA depends on the TULP3 homologues tub-1 and ktub, respectively, to activate AMPK and extend lifespan and healthspan.”
Model organismsDependent on ktub
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Nature18 Dec 2024
Lithocholic acid extends lifespan in worms.
“In nematodes and flies, LCA depends on the TULP3 homologues tub-1 and ktub, respectively, to activate AMPK and extend lifespan and healthspan.”
Model organismsDependent on tub-1
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Nature18 Dec 2024