Bed rest
Intervention1 paper3 findings
- Human trial1
Outcomes
3Peak motor-unit discharge rate and discharge-rate range
downin humans1Very low certainty
1 study
Peak motor-unit discharge rate and discharge-rate range
downin humans1Very low certainty
Bed rest decreases peak motor-unit discharge rate and discharge-rate range in humans.
Human trialhealthy young and older maleshorizontal bed restvastus lateralis21 days in young males; 10 days in older malesmales
Bed rest and endurance retraining alter persistent inward current estimates in young and older males · Frontiers in physiology · 22 Sep 2026
Motor-unit discharge acceleration and attenuation
downin humans1Very low certainty
1 study
Motor-unit discharge acceleration and attenuation
downin humans1Very low certainty
Bed rest decreases motor-unit discharge acceleration and attenuation in humans (Acceleration −25.1%; attenuation −27.7%).
Human trialhealthy young maleshorizontal bed restvastus lateralis21 daysmalesn = 9
Bed rest and endurance retraining alter persistent inward current estimates in young and older males · Frontiers in physiology · 22 Sep 2026
Persistent inward current estimate ΔF
downin humans1Very low certainty
1 study
Persistent inward current estimate ΔF
downin humans1Very low certainty
Bed rest decreases persistent inward current estimate ΔF in humans (Young: −26.1%; older: −15.3%).
Human trialhealthy young and older maleshorizontal bed restvastus lateralis21 days in young males; 10 days in older malesmales
Bed rest and endurance retraining alter persistent inward current estimates in young and older males · Frontiers in physiology · 22 Sep 2026