Cordycepin

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 5 more

Animals2

Outcomes

Vascular and cardiac remodeling

downin mice1downin rats1

1 study

Cordycepin decreases vascular and cardiac remodeling in rats.
“It ameliorated vascular and cardiac remodeling in PH rat and mouse models.”
Animalsin PH rat and mouse models
Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6 Jan 2026
Cordycepin decreases vascular and cardiac remodeling in mice.
“It ameliorated vascular and cardiac remodeling in PH rat and mouse models.”
Animalsin PH rat and mouse models
Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6 Jan 2026

Epigenetic age

downin mice1

1 study

Cordycepin decreases epigenetic age in mice.
“3dA restores clock synchrony and hormonal rhythms, including corticosterone, and reduces epigenetic age as measured by DNA methylation clocks.”
Animalsmales
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice
Cell4 Mar 2026