In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory.In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory. In 892 participants from the Singapore Chinese Health Study, researchers tracked adherence to the Dietary Approaches to Stop Hypertension (DASH) diet from…
A modeling study projects a cumulative GDP loss of INT $6.45 trillion alongside substantial increases in prevalence across mainland China from 2025 to…A modeling study projects a cumulative GDP loss of INT $6.45 trillion alongside substantial increases in prevalence across mainland China from 2025 to 2060. In mainland China, researchers projected the clinical and economic trajectory of chronic kidney disease across 31 provinces from 2025…
Oceania's life expectancy rose from 52.8 to 69.1 years between 1950 and 2023, but gains were 0.137 years per year slower than global comparators.Oceania's life expectancy rose from 52.8 to 69.1 years between 1950 and 2023, but gains were 0.137 years per year slower than global comparators. In 18 Pacific Island countries and territories, life expectancy improvements have progressed significantly slower than global benchmarks…
A meta-analysis found moderate cognitive deficits (g = -0.48) in chronic pain, and UK Biobank participants with four or more pain sites showed…A meta-analysis found moderate cognitive deficits (g = -0.48) in chronic pain, and UK Biobank participants with four or more pain sites showed advanced cognitive age. In human participants, chronic pain is associated with performance-based cognitive impairments and patterns of advanced…
In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical…In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men. In a longitudinal study of 104 older adults followed over nine years, researchers tracked how white matter signal aberrations—a…
In 218 responders and controls aged 44 to 65, cortical thickness was associated with the WTC exposure severity index at R = -0.38.In 218 responders and controls aged 44 to 65, cortical thickness was associated with the WTC exposure severity index at R = -0.38. In a neuroimaging study of 218 human responders and unexposed controls aged 44 to 65 years, researchers examined how aerosolized pollutant exposure relates to…
In Hispanic and Latino adults, a newly identified APOE cluster raised the odds of significant cognitive decline with an odds ratio of 1.47 over the…In Hispanic and Latino adults, a newly identified APOE cluster raised the odds of significant cognitive decline with an odds ratio of 1.47 over the main cluster. In a study of Hispanic and Latino adults, researchers identified a novel genetic profile in the APOE region that associates more…
Higher greenspace within 100 meters was linked to lower dementia incidence, with a hazard ratio of 0.79 overall and 0.69 in women compared to 0.93 in…Higher greenspace within 100 meters was linked to lower dementia incidence, with a hazard ratio of 0.79 overall and 0.69 in women compared to 0.93 in men. Researchers tracked 2,993 dementia-free adults aged 60 and older in Stockholm, Sweden, for 16 years in the Swedish National Study on…
Across six months, 46.3% of institutionalized older adults stayed stable, 34.4% showed gradual recovery, and 19.3% experienced progressive…Across six months, 46.3% of institutionalized older adults stayed stable, 34.4% showed gradual recovery, and 19.3% experienced progressive deterioration. In a prospective study of 295 older adults living in six Chinese long-term care facilities, researchers tracked oral frailty across six…
In 152 older rehabilitation patients, an interaction between dietary protein density and putative butyrate-producing bacteria was linked to motor…In 152 older rehabilitation patients, an interaction between dietary protein density and putative butyrate-producing bacteria was linked to motor recovery (β = 0.046). In 156 older patients undergoing post-stroke rehabilitation, researchers evaluated whether gut bacteria modify the…
Active women had lower post-menopausal progression risk (odds ratio 0.39) and somewhat active women had lower peri-menopausal onset (odds ratio 0.42)…Active women had lower post-menopausal progression risk (odds ratio 0.39) and somewhat active women had lower peri-menopausal onset (odds ratio 0.42) versus inactive peers. A longitudinal cohort study tracked 1,450 Korean women aged 42 to 52 years who underwent health examinations between…
In 5,535 women aged 70 and older, endogenous oestradiol concentrations showed no association with major cardiovascular events or all-cause mortality…In 5,535 women aged 70 and older, endogenous oestradiol concentrations showed no association with major cardiovascular events or all-cause mortality over 4.5 years of follow-up.
In a cross-sectional study of 4,124 women, loneliness alone was associated with higher Greene Climacteric Scale scores and severe menopausal symptom…In a cross-sectional study of 4,124 women, loneliness alone was associated with higher Greene Climacteric Scale scores and severe menopausal symptom burden (OR = 1.68). In a cross-sectional study of 4,124 women from the nationwide web-based CLIMATERE cohort, researchers evaluated how…
In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and…In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and 13.8% of putamen samples.
Compared with unexposed cohorts, exposure at ages 0–3 and 4–11 was associated with a 0.021 and 0.042 rise in later-life frailty, appearing only in…Compared with unexposed cohorts, exposure at ages 0–3 and 4–11 was associated with a 0.021 and 0.042 rise in later-life frailty, appearing only in men. In a study of 19,426 individuals in China born between 1910 and 1968, researchers examined the long-term health consequences of exposure…
Among men 80 or older, adjusted PSA testing was 187.9 per 1000 person-years in VA care against 267.9 in fee-for-service Medicare.Among men 80 or older, adjusted PSA testing was 187.9 per 1000 person-years in VA care against 267.9 in fee-for-service Medicare. In a retrospective cohort of 1.41 million male veterans aged 65 years or older dually enrolled in the VA and fee-for-service Medicare, researchers examined…
Normal pulmonary function showed an adjusted hazard ratio of 0.62 for dementia compared with airflow limitation, while moderate obstruction showed an…Normal pulmonary function showed an adjusted hazard ratio of 0.62 for dementia compared with airflow limitation, while moderate obstruction showed an adjusted hazard ratio of 1.87.
In 22,205 older adults followed for 12.3 years, complete tooth loss increased the transition risk from mild cognitive impairment to dementia with a…In 22,205 older adults followed for 12.3 years, complete tooth loss increased the transition risk from mild cognitive impairment to dementia with a hazard ratio of 1.26. A prospective cohort study evaluated 22,205 adults aged 50 years or older from China, the United States, and England…
In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher…In 957 non-demented adults, social isolation was associated with lower cognitive scores, decreased cerebrospinal fluid amyloid-beta levels, and higher tau-to-amyloid ratios. In a cross-sectional study of 957 non-demented adults from the Chinese Alzheimer's Biomarker and LifestyLE study…
The Canadian Journal of Neurological Sciences Le Journal Canadien des Sciences NeurologiquesHumans·
Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males.Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males. In a retrospective cohort study of 59,346 adults hospitalized with ischemic stroke in Ontario, Canada, researchers examined how age and frailty relate…
