MechanismsReview
A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course

International Journal of Molecular Sciences
Abstract
A strong body of evidence is established that links sex-hormone-regulated physiological processes across the female life course with increased risk of osteoarthritis (OA), although the strength and nature of these associations vary by joint site and OA phenotype.
The paper
Larissa Rix, Nicola J. Kuiper, Andrew G. Marshall, Karina Wright
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Charlotte H. Hulme, Neve O’Hare, Christoph H. Ladel, Alzbeta Chabronova, Dharani Kosala Hapangama, Martyn Snow, Deborah J. Mason, Mandy Peffers,Robert Jones and Agnes Hunt Orthopaedic Hospital
International Journal of Molecular Sciences · 11 Sep 2026 · CC BY