Metabolic and vascular markers linked to angle-closure glaucoma

In a prospective cohort of 499,102 adults aged 30 to 79 from the China Kadoorie Biobank, researchers tracked probable primary angle-closure glaucoma incidence over a median of 15.7 years. The team evaluated 117 exposures spanning sociodemographics, lifestyle, medical history, and physical measurements, ascertaining 3,266 incident cases. After multiple testing correction, 26 factors were independently associated with probable angle-closure glaucoma. Age, female sex, and postmenopausal status showed the strongest positive associations. Markers of metabolic and vascular aging, including diabetes, higher random plasma glucose, larger waist circumference, and elevated pulse pressure, were associated with higher risk, while body mass index showed an inverse association. Peptic ulcer, daily dairy, and daily preserved vegetables were also linked to higher risk, whereas higher physical activity and weekly tea consumption were associated with lower risk.