Cardiac dysfunction
Disease2 papers2 findings
- Animals2
Interventions
2Astragaloside iv
downin mice1
1 study
Astragaloside iv
downin mice1
Astragaloside iv decreases cardiac dysfunction in mice.
Animalsaging-inducedheart
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026
CD47 antibody
downin mice1
1 study
CD47 antibody
downin mice1
CD47 antibody decreases cardiac dysfunction in mice.
“and improved doxorubicin-induced cardiac dysfunction.”
Animalsdoxorubicin-inducedheartmales
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice · Physiological reports · 1 Sep 2026
Latest
2Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.
Physiological reports · Yan A et al.