TET2
Gene3 papers1 findingHGNC 25941MGI 2443298NCBI Gene 54790Taxon 9606
- Humans2
- Animals1
Effects
1Physical function
downin mice1
1 study
Physical function
downin mice1
TET2 impairs physical function in mice.
Animalsmouse model
Somatic blood mutations associate with accelerated frailty and functional decline in humans · medRxiv · 1 Oct 2026 · Preprint
Latest
3TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification…Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.