1 paper3 findings
Body mass index
upin humans1
Body mass index raises the risk of Alzheimer's disease and dementia in humans.
“high‐SDI countries bearing the greatest burden due to modifiable risk factors like fasting plasma glucose and BMI”
Humansin high-SDI countries
AAIC 2025 abstract23 Dec 2025
Fasting plasma glucose
upin humans1
Fasting plasma glucose raises the risk of Alzheimer's disease and dementia in humans.
“high‐SDI countries experiencing the highest burden, driven primarily by elevated fasting plasma glucose and BMI”
Humansin high-SDI countries
AAIC 2025 abstract23 Dec 2025
Mortality
no changein humans1
Alzheimer's disease and dementia is associated with mortality in humans (AAPC 0.004%, 95% CI: -0.0072 to 0.0178).
“Globally, the age‐standardized death rate (ASDR) for Alzheimer's disease and other dementias remained constant from 1990 to 2021 (AAPC: 0.004%; 95% CI: ‐0.0072 to 0.0178)”
Humans
AAIC 2025 abstract23 Dec 2025
Each 10,000 particles/cm³ increase in outdoor ultrafine particle concentrations was associated with higher dementia mortality (hazard ratio 1.22, 95% CI 1.17–1.27).Each 10,000 particles/cm³ increase in outdoor ultrafine particle concentrations was associated with higher dementia mortality (hazard ratio 1.22, 95% CI 1.17–1.27).
A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.
Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors.Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors.
In 22,205 older adults followed for 12.3 years, complete tooth loss increased the transition risk from mild cognitive impairment to dementia with a hazard ratio of 1.26.In 22,205 older adults followed for 12.3 years, complete tooth loss increased the transition risk from mild cognitive impairment to dementia with a hazard ratio of 1.26.