KDM-based age acceleration

1. Cardiac dysfunction is associated with KDM-based age acceleration in humans (β = 7.89 (95% CI 3.11–12.66)).

   “followed by cardiac dysfunction (β = 7.89, 95% CI: 3.11-12.66).”

   HumansAcute ischemic stroke; latent multimorbidity patternsn = 2,539

   Association of multimorbidity with biological age acceleration in acute ischemic stroke patients: a cross-sectional study

   QJM : monthly journal of the Association of Physicians·3 Jul 2025

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1. Hyperglycemia-hypertension pattern is associated with KDM-based age acceleration in humans (β = 11.59 (95% CI 9.61–13.58)).

   “Among multimorbidity patterns, the hyperglycemia-hypertension pattern showed the strongest association with KDM-AA (β = 11.59, 95% CI: 9.61-13.58)”

   HumansAcute ischemic stroke; latent multimorbidity patternsn = 2,539

   Association of multimorbidity with biological age acceleration in acute ischemic stroke patients: a cross-sectional study

   QJM : monthly journal of the Association of Physicians·3 Jul 2025

More on Hyperglycemia-hypertension pattern

1. Multimorbidity is associated with KDM-based age acceleration in humans (+3.78 years per additional chronic condition (95% CI 3.00–4.55)).

   “Each additional chronic condition was associated with a 3.78-year increase in KDM-based age acceleration (95%CI: 3.00-4.55, fully adjusted)”

   HumansAcute ischemic stroke; per additional chronic condition; fully adjustedn = 2,539

   Association of multimorbidity with biological age acceleration in acute ischemic stroke patients: a cross-sectional study

   QJM : monthly journal of the Association of Physicians·3 Jul 2025

More on Multimorbidity