Voluntary wheel running
Intervention1 paper3 findings
- Animals1
Outcomes
3Synapse density
no changein mice1Very low certainty
1 study
Synapse density
no changein mice1Very low certainty
Voluntary wheel running has no effect on synapse density in mice.
Animalshippocampus
Voluntary running shows limited neuroprotection in mice · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Behavioral function
no changein mice1Very low certainty
1 study
Behavioral function
no changein mice1Very low certainty
Voluntary wheel running has no effect on behavioral function in mice.
Animalshippocampus
Voluntary running shows limited neuroprotection in mice · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Amyloid pathology
no changein mice1Very low certainty
1 study
Amyloid pathology
no changein mice1Very low certainty
Voluntary wheel running has no effect on amyloid pathology in mice.
Animalshippocampus
Voluntary running shows limited neuroprotection in mice · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Latest
1Voluntary running shows limited neuroprotection in mice
In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology…In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.