Mechanisms
Tue 29 Sep35 papers
T cell KRAS upregulation is linked to premature coronary disease
Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery…Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease. In human blood and tissue samples, researchers investigated whether aging-related gene dysregulation in T cells contributes to premature…
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics. In a preprint analyzing mice and human liver cirrhosis tissue, researchers investigated a distinct macrophage senotype characterized by…
Attention follows an inverted-U lifespan curve in macaques
Longitudinal behavioral testing and resting-state fMRI in semi-free-ranging macaques linked aging and social status to frontoparietal brain…Longitudinal behavioral testing and resting-state fMRI in semi-free-ranging macaques linked aging and social status to frontoparietal brain connectivity. In semi-free-ranging macaques living in naturalistic social groups, attentional performance follows an inverted-U trajectory across the…
Female hypertension links to a blood gene signature
Across 193 GTEx and 1,605 Framingham Heart Study participants over 55, females with uncontrolled high blood pressure showed a distinct, suppressed…Across 193 GTEx and 1,605 Framingham Heart Study participants over 55, females with uncontrolled high blood pressure showed a distinct, suppressed blood transcriptomic signature.
A cortical alpha-beta rhythm gradient decays with age
Task-free magnetoencephalography of 604 participants showed a continuous alpha-to-beta cortical gradient that correlates positively with cognition and…Task-free magnetoencephalography of 604 participants showed a continuous alpha-to-beta cortical gradient that correlates positively with cognition and decays with age. In a study of 604 human participants, researchers analyzed task-free magnetoencephalography data to map resting brain…
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation. In a preprint study, researchers found that chronic DHA deficiency in mice triggers a neural-tissue-selective lipid shift from DHA-containing…
Brain and pituitary gene regulation links to the timing of natural menopause
A large genomic study prioritized hundreds of genetic variants and highlighted candidate cell-type-specific targets associated with female…A large genomic study prioritized hundreds of genetic variants and highlighted candidate cell-type-specific targets associated with female reproductive aging. In a preprint analyzing genomic data from 173,424 women of European ancestry, researchers investigated regulatory mechanisms…
KLF-1 regulates SKN-1 activity and longevity in worms
In germline-deficient animals, KLF-1 was required for SKN-1 activation, oxidative stress resistance, and longevity without altering skn-1 transcript…In germline-deficient animals, KLF-1 was required for SKN-1 activation, oxidative stress resistance, and longevity without altering skn-1 transcript abundance. In Caenorhabditis elegans, researchers investigated how Krüppel-like factors coordinate lipid metabolism with stress resistance…
White matter damage is linked to greater cortical thinning in men
In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical…In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men. In a longitudinal study of 104 older adults followed over nine years, researchers tracked how white matter signal aberrations—a…
Age-related changes in sustained visual attentional modulation of audiovisual integration
UHRF1 levels drive distinct senescent states in zebrafish liver cells
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated. In zebrafish hepatocytes, researchers examined how overexpressing the epigenetic regulator UHRF1 drives senescent cell diversity during preneoplastic…
Germline HRD limits therapy-driven clonal hematopoiesis
Serial blood samples revealed carboplatin and PARP inhibitors expand DNA damage response clones, though germline homologous recombination deficiency…Serial blood samples revealed carboplatin and PARP inhibitors expand DNA damage response clones, though germline homologous recombination deficiency reduces this growth. In human cancer patients and a mouse model of Trp53-mutated clonal hematopoiesis, researchers analyzed how therapies…
Ramadan fasting is linked to respiratory sarcopenia in older men
In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both…In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both sexes. In a study of 53 older men and 48 older women observing Ramadan, researchers tracked markers of respiratory sarcopenia alongside…
Partial Y chromosome loss alters transcription in cancer cells
Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to…Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to transcriptional changes. In male cancer cell lines, researchers investigated somatic loss of the Y chromosome, the most frequent acquired genomic…
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age. In humans, mice, and pigs, aged placentas exhibit increased macrophage CD38 expression and NAD+ deficiency.
Microglial ALKBH5 loss protects fat browning in aging male mice
Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice. In male mice, researchers examined how hypothalamic microglia regulate sympathetic innervation and adipose tissue browning.
Persistent IFN-γ links to worse cardiac remodeling in aged mice
In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with…In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac remodeling.
ASXL1 clonal hematopoiesis is linked to lung cancer risk
In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among…In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers. In human cohorts, researchers evaluated gene-specific clonal hematopoiesis of indeterminate potential (CHIP) across 19 common solid…
Sarcopenia as a manifestation of systemic energetic failure with ageing
Mineralized brain vessels vary by region in Alzheimer disease
In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and…In an autopsy study of 265 decedents, vessel mineralization appeared in 58.3% of globus pallidus samples, 28.6% of posterior hippocampus samples, and 13.8% of putamen samples.
Rates of Lipoprotein(a) Oxidation Accelerate at Elevated Levels and Attenuate With Atorvastatin Active Metabolites Compared With Other Statins
NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages
Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages. In aged bone marrow-derived macrophages, researchers investigated the functional remodeling of the NLRP3 inflammasome during aging.
Vascular reactivity and gray matter shape executive function
In 120 older adults, cerebrovascular reactivity and gray matter volume interacted in parietal and occipital lobes to influence executive function.In 120 older adults, cerebrovascular reactivity and gray matter volume interacted in parietal and occipital lobes to influence executive function. In a study of 181 healthy younger adults aged 18 to 34 and 120 older adults aged 60 to 89, researchers evaluated how cerebrovascular reactivity…