The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway. In female mice experiencing reproductive aging, administration of the peptide elamipretide increased litter size and ameliorated age-related declines in oocyte…
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15. In ApoE-/- mice fed a high-fat diet for 12 weeks, treatment with rapamycin (1 mg/kg twice weekly for 4 weeks) reduced…
The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic…The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.
In adults with diabetes or obesity, three-point major adverse cardiovascular events dropped to 4.1 per 1000 person-years versus 9.3 in matched…In adults with diabetes or obesity, three-point major adverse cardiovascular events dropped to 4.1 per 1000 person-years versus 9.3 in matched controls. In a retrospective claims-based cohort of 4,877 adults with type 2 diabetes or obesity, researchers evaluated cardiovascular outcomes…
Early statin initiation was associated with a 15% lower 10-year relative risk of dementia compared to no statin treatment in people with type 2…Early statin initiation was associated with a 15% lower 10-year relative risk of dementia compared to no statin treatment in people with type 2 diabetes. Researchers analyzed nationwide Danish health registers tracking 132,585 statin-naïve adults who developed type 2 diabetes between 2006…
In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering…In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering coprimary imaging endpoints. In 106 people with type 2 diabetes and chronic kidney disease, researchers evaluated subcutaneous semaglutide (1 mg…
Adjusted sexual quality of life scores were 7.7 points higher with nettle cream than with placebo after eight weeks of treatment.Adjusted sexual quality of life scores were 7.7 points higher with nettle cream than with placebo after eight weeks of treatment. In an eight-week randomized trial, researchers evaluated 84 postmenopausal women aged 45 to 60 years who had vaginal atrophy.
At 36 months, early ablation was linked to 1.54 more event-free months and an 11.17% absolute risk reduction in major adverse cardiovascular events…At 36 months, early ablation was linked to 1.54 more event-free months and an 11.17% absolute risk reduction in major adverse cardiovascular events versus medical therapy. In a retrospective study of 431 human patients aged 18 to 85 years with atrial fibrillation and a history of ischemic…
Mailed programmes increased lifetime and past-2-year screening uptake by 28.3 and 30.2 percentage points, respectively, compared with countries…Mailed programmes increased lifetime and past-2-year screening uptake by 28.3 and 30.2 percentage points, respectively, compared with countries without them. In a study of 202,976 European adults aged 50 to 74, researchers examined how nationwide mailed faecal immunochemical test (FIT)…
Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor. In a real-world study of 12,808 heart failure patients, researchers investigated whether using an angiotensin receptor-neprilysin inhibitor (ARNI) influenced…
Weekly survodutide cut body weight by up to 9.8% at 76 weeks compared to a 3.9% reduction with placebo.Weekly survodutide cut body weight by up to 9.8% at 76 weeks compared to a 3.9% reduction with placebo. In a phase 3 trial involving 752 adults with type 2 diabetes and a body-mass index of 27 or higher, weekly survodutide significantly reduced body weight over 76 weeks.
A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in…A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease. In humans, researchers analyzed genome-wide association study summary data using Mendelian randomization to evaluate causal links…
Baseline protein profiles stratified 12-week physical gains from rehabilitation over control, spanning 10 to 85 meters on the six-minute walk test.Baseline protein profiles stratified 12-week physical gains from rehabilitation over control, spanning 10 to 85 meters on the six-minute walk test. In a preprint analyzing 243 hospitalized adults aged 60 and older with heart failure from the REHAB-HF trial, baseline blood proteins…
In a preprint comparing women across menopausal stages, at least six weeks of vaginal estrogen tracked with more lactobacilli and fewer opportunistic…In a preprint comparing women across menopausal stages, at least six weeks of vaginal estrogen tracked with more lactobacilli and fewer opportunistic pathogens. In women across menopausal stages, vaginal estrogen therapy is linked to a urinary microbiome that more closely resembles…
In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology…In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory. In 5xFAD mice, prolonged exercise failed to generate broad neuroprotective benefits despite engaging peripheral metabolism…
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in…The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes. Researchers evaluated Gastrodia elata polysaccharide in BV2 microglia, Caenorhabditis elegans, and naturally aging mice.
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular…A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion. In cultured human exfoliated deciduous tooth stem cells, researchers identified the phytochemical melissic acid as a candidate to counter…
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage. In human patients with chronic inflammatory demyelinating polyneuropathy and in mice with CIDP-like disease, researchers found elevated…
Reducing dietary cysteine independently of methionine enhanced survival in nematodes and reprogrammed the immunometabolic axis in mice.Reducing dietary cysteine independently of methionine enhanced survival in nematodes and reprogrammed the immunometabolic axis in mice. In Caenorhabditis elegans and mice, researchers investigated whether reducing cysteine instead of methionine drives the longevity benefits associated with…
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy. In aged mice, inhibiting the microRNA miR-128-3p with antisense oligonucleotides restored muscle mass and function, according to a recent preprint.
Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue.Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue. In studies of human myoblasts and mice, researchers investigated how extracellular vesicles guide skeletal muscle repair.
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence…The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers. In a phase-2 randomized controlled trial, 31 human participants with fibrotic metabolic dysfunction-associated steatohepatitis…
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without…A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity. In a new preprint, researchers tested retinal pigment epithelium cells and aging mice to discover genes that confer resistance…
