Interventions
TodayMon 5 OctMonday 5 October19 papers
Low-intensity exercise eases age-related osteoarthritis in mice
In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect…In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints. In aged mice, low-intensity swimming exercise attenuated age-related osteoarthritis.
GLP-1 agonists linked to lower dementia risk after COVID-19
GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19…GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors. In a study of COVID-19 survivors aged 50 years and older with type 2 diabetes, researchers compared the outcomes of initiating…
Study design, rationale, and baseline characteristics of ATTAIN-HYPERTENSION, a phase 3 trial of the oral GLP-1 receptor agonist orforglipron for hypertension
Supraphysiological ascorbic acid infusion attenuates cerebrovascular dysfunction in middle-aged and older adults
Glucagon-Like Peptide-1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications
A 5:2 fasting regimen curbs muscle impairment in mice
Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without…Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without altering cumulative energy intake.
Nicotinamide riboside improves parasite control in mice
In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and…In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle. In mice infected with the parasite Trypanosoma cruzi, treatment with nicotinamide riboside improved immune control by…
YesterdaySun 4 OctSunday 4 October23 papers
Light- and enzyme-gated prodrugs target senescent cells
Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.
Direct conversion to neural stem cells de-ages human blood cells
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…
The effects of chronic beetroot juice supplementation with resistance training on skeletal muscle mitochondrial and redox markers in middle-aged and older adults
Effect of interventions for stress management on blood pressure changes in healthy adults: a systematic review and meta-analysis
Baguazhang lowers systolic blood pressure in postmenopausal women
In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle.In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle. Forty-six sedentary postmenopausal women enrolled in a 12-week randomized controlled trial evaluating Baguazhang, a traditional Chinese mind-body…
Fungus drives spleen aging in mice, eased by astragaloside IV
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis. In aged mice, exposure to the fungus Kazachstania pintolopesii accelerates splenic senescence, according to a study…
Effects of corn-derived dietary fibers on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
Statins are associated with decreased risk of disease progression and death in non-cirrhotic patients with primary biliary cholangitis
Exercise, Glucose and Lactate Metabolism in Mild Cognitive Impairment: A Narrative Review
Treatment-dependent association between sarcopenia and ADL at discharge after osteoporotic vertebral fractures
Design of an Early Exercise Program for Hospitalized Patients: "Let's Move"
Change in cascade of care among individuals with hypertension - India hypertension control initiative, 2018-2024
Aspirin initiation before 65 links to lower Alzheimer's risk
Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk. In human health records and cortical organoids, researchers evaluated aspirin as a repurposed candidate against…
Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial
