NFE2L1

1. NFE2L1 activates ubiquitin–proteasome system.

   “nuclear factor-erythroid 2-like bZIP factor 1 (NFE2L1, also known as Nrf1, with its long isoform TCF11 and short isoform LCR-F1) has been identified as an indispensable regulator of the transcriptional expression of the ubiquitin-proteasome system.”

   Review

   NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases

   Redox biology·Dec 18, 2023

2. NFE2L1 activates ubiquitin–proteasome system.

   “Nuclear factor erythroid 2- like 1 (NFE2L1) is a transcription factor primarily responsible for the proteasome inhibitor-induced "bounce-back effect" regulating the expression of proteasome subunits.”

   Review

   Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases

   Biology·Aug 25, 2023

More on Ubiquitin–proteasome system

1. NFE2L1 improves autophagy in C. model cells.

   “Nrf1α-/- deficiency leads to STAG2- and SMC3-dependent chromosomal stability disruption and autophagy dysfunction”

   Cellsshown by gene deletion

   Deletion of Nrf1α exacerbates oxidative stress-induced cellular senescence by disrupting cell homeostasis

   Biochimica et biophysica acta. Molecular cell research·Apr 23, 2025

More on Autophagy

1. NFE2L1 prevents cellular senescence in C. model cells.

   “deletion of Nrf1α significantly elevates senescence characteristics in Nrf1α-/--deficient cells”

   Cellsshown by gene deletion

   Deletion of Nrf1α exacerbates oxidative stress-induced cellular senescence by disrupting cell homeostasis

   Biochimica et biophysica acta. Molecular cell research·Apr 23, 2025

More on Cellular senescence