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eff

Gene

3 papers5 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Model organisms3

Effects

3

huntingtin-polyQ degradation

is required forin flies2

2 studies

  1. eff is required for huntingtin-polyQ degradation in flies.

    “UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation.”

    Model organismsaggregation-prone huntingtin-polyQ modelretina

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    eLife3 Jul 2024Preprint

  2. eff is required for huntingtin-polyQ degradation in flies.

    “UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation.”

    Model organismsin Drosophila retinaretina

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    eLife26 Feb 2024Preprint

Insoluble poly-ubiquitinated proteins

downin flies2

2 studies

  1. eff decreases insoluble poly-ubiquitinated proteins in flies.

    “muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins”

    Model organismsmuscle-specific knockdownskeletal muscle

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    eLife26 Feb 2024Preprint

  2. eff decreases insoluble poly-ubiquitinated proteins in flies.

    “muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins (which progressively accumulate with aging) and shortens lifespan.”

    Model organismsmuscle-specific eff knockdownskeletal muscle

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    eLife26 Feb 2024Preprint

More on Insoluble poly-ubiquitinated proteins

Lifespan

downin flies1

1 study

  1. eff shortens lifespan in flies.

    “muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins (which progressively accumulate with aging) and shortens lifespan.”

    Model organismsmuscle-specific eff knockdownskeletal muscle

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    eLife26 Feb 2024Preprint

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