Thiolutin

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
1 finding against

Cells1

Outcomes

Ubiquitin–proteasome system

upin yeast cells1

1 study

Thiolutin activates ubiquitin–proteasome system in yeast cells.
“In parallel, thiolutin triggers a selective adaptive response with activation of RPN4-mediated proteasome remodeling and redox-responsive genes, without HOG1 induction.”
Cells
Thiolutin extends replicative lifespan by rewiring yeast transcription and metabolism
Scientific reports1 Mar 2026

Latest

1 in 12 months

Scientific Reports2 Mar

Thiolutin extends replicative lifespan by rewiring yeast transcription and metabolism

Experiments in yeastOxidative phosphorylation

Paper

Thiolutin

Outcomes

Latest

Thiolutin extends replicative lifespan by rewiring yeast transcription and metabolism

Related