Muscle atrophy
Disease7 papers8 findings
In mouse studies, muscle atrophy is induced by disuse immobilization or skeletal muscle DEPP1 overexpression, and mediated by Hif1a under hypoxia. It is reduced by aerobic exercise, MDIVI-1, CRLS1 restoration, PRODH2 knockdown, or DEPP1 knockout.
- Humans1
- Animals4
- Cells2
Interventions
7PRODH2 knockdown
downin mice1
1 study
PRODH2 knockdown
downin mice1
PRODH2 knockdown decreases muscle atrophy in mice.
Animalsin vivomuscle-specific knockdownskeletal muscle
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026
CRLS1 restoration
downin mice1
1 study
CRLS1 restoration
downin mice1
CRLS1 restoration decreases muscle atrophy in mice.
Animalsin adult Crls1 knockout miceskeletal muscle
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026
DEPP1 overexpression
upin mice1
1 study
DEPP1 overexpression
upin mice1
DEPP1 overexpression induces muscle atrophy in mice.
Animalsskeletal muscle overexpressionskeletal muscle
Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint
DEPP1 knockout
downin mice1
1 study
DEPP1 knockout
downin mice1
DEPP1 knockout decreases muscle atrophy in mice.
Animalsunder fasting and hypoxiawhole-body knockoutskeletal muscle
Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint
Unilateral immobilization
upin mice1
1 study
Unilateral immobilization
upin mice1
Unilateral immobilization induces muscle atrophy in mice.
Animalsdisuseskeletal muscle
Loss of myofibril number drives muscle fibre atrophy during aging and disuse · The Journal of physiology · 25 Sep 2026
MDIVI-1
downin mice1
1 study
MDIVI-1
downin mice1
MDIVI-1 decreases muscle atrophy in mice.
“Mdivi-1 treatment produced similar protective effects, including attenuation of skeletal muscle atrophy, oxidative stress, and inflammatory responses.”
AnimalsHFD-fed miceskeletal muscle
Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission · Antioxidants (Basel, Switzerland) · 31 Aug 2026
Aerobic exercise
downin mice1
1 study
Aerobic exercise
downin mice1
Aerobic exercise decreases muscle atrophy in mice.
“Aerobic exercise reduced Drp1 phosphorylation, oxidative stress, and inflammatory responses in the skeletal muscle of HFD-fed mice and attenuated skeletal muscle atrophy.”
AnimalsHFD-fed miceskeletal muscle8-week
Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission · Antioxidants (Basel, Switzerland) · 31 Aug 2026
Upstream
1Hif1a
mediatesin mice1
1 study
Hif1a
mediatesin mice1
Hif1a mediates muscle atrophy in mice.
Animalsunder hypoxiaskeletal muscle
Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint
Latest
12Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
bioRxiv : the preprint server for biology · Son W et al.
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
bioRxiv · Grafton F et al.
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
Nature aging · Finger F et al.
Depp1 drives muscle loss under fasting and low oxygen in mice
The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.
bioRxiv · Qayyum S et al.
Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice
A specialized encapsulation system slows protein digestion to boost muscle signaling and physical endurance in a murine sarcopenia model.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Zhang Y et al.
Loss of myofibril number drives muscle fibre atrophy during aging and disuse
Structural analyses of humans and mice reveal that fibers shrink primarily by shedding myofibrils rather than reducing myofibril size.
The Journal of physiology · Sayed RKA et al.