Whole grains
Intervention4 papers8 findingsMeSH D000067348
A human trial reports that whole grains at 48 g/day reduce body weight, total cholesterol, IL-6 and systolic blood pressure. Another human trial reports lower plasma atherogenic index, triglyceride–glucose index and triglycerides over 12 weeks.
- Human trial1
Outcomes
7IL-6
downin humans1High certainty
1 study
IL-6
downin humans1High certainty
Whole grains decrease IL-6 in humans (MD: -.12 pg/mL; 95% CI: -.23 to -.00).
Human trial48 g/day
Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials · European heart journal · 15 Sep 2026
Systolic blood pressure
downin humans1High certainty
1 study
Systolic blood pressure
downin humans1High certainty
Whole grains decrease systolic blood pressure in humans (-.82 mmHg; 95% CI: -1.49 to -.15).
Human trial48 g/day
Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials · European heart journal · 15 Sep 2026
Total cholesterol
downin humans1High certainty
1 study
Total cholesterol
downin humans1High certainty
Whole grains decrease total cholesterol in humans (-.10 mmol/L; 95% CI: -.13 to -.07).
Human trial48 g/day
Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials · European heart journal · 15 Sep 2026
Body weight
downin humans1High certainty
1 study
Body weight
downin humans1High certainty
Whole grains decrease body weight in humans (MD: -.20 kg; 95% CI: -.31 to -.09).
Human trial48 g/day
Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials · European heart journal · 15 Sep 2026
Triglyceride-glucose index
downin humans1Moderate certainty
1 study
Triglyceride-glucose index
downin humans1Moderate certainty
Whole grains decrease triglyceride-glucose index in humans (β = -0.301, -0.429 to -0.173).
Human trialHWG versus control12-week
Whole-Grain Staple Replacement and Cardiometabolic Phenotypes in Adults at High Risk of Type 2 Diabetes: An Extended Randomized-Trial Analysis with NHANES and Country-Level Context · Nutrients · 23 Aug 2026
Atherogenic index of plasma
downin humans1Moderate certainty
1 study
Atherogenic index of plasma
downin humans1Moderate certainty
Whole grains decrease atherogenic index of plasma in humans (β = -0.125, -0.191 to -0.060).
Human trialHWG versus control12-week
Whole-Grain Staple Replacement and Cardiometabolic Phenotypes in Adults at High Risk of Type 2 Diabetes: An Extended Randomized-Trial Analysis with NHANES and Country-Level Context · Nutrients · 23 Aug 2026
Triglyceride
downin humans1Moderate certainty
1 study
Triglyceride
downin humans1Moderate certainty
Whole grains decrease triglyceride in humans (β = -0.220, 95% CI -0.397 to -0.043).
Human trialHWG versus control12-week
Whole-Grain Staple Replacement and Cardiometabolic Phenotypes in Adults at High Risk of Type 2 Diabetes: An Extended Randomized-Trial Analysis with NHANES and Country-Level Context · Nutrients · 23 Aug 2026
Associations
1Endometrial cancer
downin humans1RR 0.9Low certainty
1 study
Endometrial cancer
downin humans1RR 0.9Low certainty
Whole grains lower the risk of endometrial cancer in humans (RR 0.90, 95% CI 0.84-0.98).
Review
Healthy dietary patterns, typical healthy foods and risk of endometrial cancer: a systematic review and meta-analysis of observational studies · Frontiers in oncology · 12 Aug 2026