LDL cholesterol

1. Diet decreases LDL cholesterol in humans.

   “LDL-cholesterol decreased in both Opti and LCHF Opti groups versus control”

   Human trial4 weeks

   Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial · Scientific reports · 3 Oct 2026

Diet →

1. Tirzepatide decreases LDL cholesterol in humans.

   Humanstype 2 diabetes4.5 ± 1.0 mg/week24 weeksn = 88

   Real-world effectiveness and safety of low-dose tirzepatide in Japanese people with type 2 diabetes: a multicenter, retrospective, single-arm, observational study-East Shizuoka Tirzepatide (ESTATE) study · Endocrine journal · 29 Sep 2026

Tirzepatide →

1. Statins decrease LDL cholesterol in humans (donut estimates vary from - 1.00 to - 1.72 mmol/L).

   Humansaround the first recorded prescription date

   Event-time regression discontinuity for biomedical data: LATT estimation and covariate distribution tests · American journal of epidemiology · 29 Sep 2026

Statins →

1. Inclisiran decreases LDL cholesterol in humans (-46% (-60.8 to -33.8%)).

   Humans3 years43.1% femalesn = 109

   Long-term LDL-C lowering and treatment persistence with inclisiran: 3-year follow-up from the German Inclisiran Network · Clinical research in cardiology : official journal of the German Cardiac Society · 28 Sep 2026

Inclisiran →

1. Lerodalcibep decreases LDL cholesterol in humans (50% to 65%).

   Reviewin patients with heterozygous familial hypercholesterolemia, established cardiovascular disease, or high cardiovascular riskmonthly

   Lerodalcibep-liga as an Injectable Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)-Targeted Therapy for Patients With Hypercholesterolemia · The Annals of pharmacotherapy · 25 Sep 2026

Lerodalcibep →

1. Mediterranean diet decreases LDL cholesterol in humans.

   Review

   Lifestyle Medicine and the Science of Cholesterol Reduction: A Systematic Review of Non-medication Approaches Among Adults · Cureus · 30 Aug 2026

Mediterranean diet →

1. Cysteine-glutathione disulfide increases LDL cholesterol in humans.

   “Genetically predicted 2-amino-octanoate and cysteine-glutathione disulfide demonstrated strong and reproducible positive interaction effects with LDL levels in statin users”

   Humansin statin users

   Gene-Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits · Pharmaceuticals (Basel, Switzerland) · 17 Sep 2026

Cysteine-glutathione disulfide →

1. 2-amino-octanoate increases LDL cholesterol in humans.

   “Genetically predicted 2-amino-octanoate and cysteine-glutathione disulfide demonstrated strong and reproducible positive interaction effects with LDL levels in statin users”

   Humansin statin users

   Gene-Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits · Pharmaceuticals (Basel, Switzerland) · 17 Sep 2026

2-amino-octanoate →

1. APOE is associated with LDL cholesterol in humans.

   Reviewε4 isoform

   Apolipoprotein E ε3/ε4 and coronary artery disease: lipid and non-lipid mechanisms in personalized prevention - narrative review · Frontiers in cardiovascular medicine · 18 Sep 2026

APOE →