nlp-99

1. nlp-99 is required for sleep in worms.

   “NLP-99/NPR-16 signaling is required for RIS activation and sleep while also inhibiting longevity via RIS.”

   Model organismsin well-fed adults

   C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

   Science advances·15 Apr 2026

1. nlp-99 is required for memory consolidation in worms.

   “Both NLP-99/NPR-16 and RIS/FLP-11 are required for memory consolidation.”

   Model organismswell-fed adults

   C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

   Science advances·15 Apr 2026

1. nlp-99 shortens lifespan in worms.

   “NLP-99/NPR-16 signaling is required for RIS activation and sleep while also inhibiting longevity via RIS.”

   Model organismsin well-fed adults

   C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

   Science advances·15 Apr 2026

1. nlp-99 decreases lipid and ceramide metabolism in worms.

   “During larval arrest, strong NPR-16 expression in RIS causes NLP-99/NPR-16 signaling to inhibit sleep, reducing lipid storage and survival.”

   Model organismsduring larval arrest

   C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

   Science advances·15 Apr 2026

More on Lipid and ceramide metabolism

1. nlp-99 decreases survival in worms.

   “During larval arrest, strong NPR-16 expression in RIS causes NLP-99/NPR-16 signaling to inhibit sleep, reducing lipid storage and survival.”

   Model organismsduring larval arrest

   C. elegans somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron

   Science advances·15 Apr 2026