Aortic valve stenosis
Disease1 paper1 finding
- Humans1
Associations
1ASXL1
upin humans1
1 study
ASXL1
upin humans1
ASXL1 is associated with aortic valve stenosis in humans.
Humanslarge CHIP clones and non-DNMT3A CHIP subtypesn = 449,109
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification · medRxiv · 29 Sep 2026 · Preprint
Latest
1ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.