Monounsaturated fatty acids

Biomarker2 papers5 findings

A human Mendelian randomisation study links monounsaturated fatty acids to higher risks of hypertension, ischaemic heart disease, angina and myocardial infarction. A human trial shows 12-day fasting reduces these fatty acids in adipose tissue.

Human trial1
Humans1

Interventions

Fasting

downin humans1Very low certainty

1 study

Fasting decreases monounsaturated fatty acids in humans.
Human trialadipose tissue12-day
Impact of long-term fasting on liver and abdominal adipose tissues monitored by quantitative chemical-shift encoded MRI · Frontiers in nutrition · 7 Sep 2026

Fasting →

Associations

Hypertension

upin humans1OR 1.021

1 study

Monounsaturated fatty acids raise the risk of hypertension in humans (OR 1.021, 95% CI 1.011–1.031).
HumansMendelian randomization
High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study · Iranian journal of medical sciences · 1 Aug 2026

Hypertension →

Myocardial infarction

upin humans1OR 1.007

1 study

Monounsaturated fatty acids raise the risk of myocardial infarction in humans (OR 1.007, 95% CI 1.004–1.009).
HumansMendelian randomization
High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study · Iranian journal of medical sciences · 1 Aug 2026

Myocardial infarction →

Ischemic heart disease

upin humans1OR 1.015

1 study

Monounsaturated fatty acids raise the risk of ischemic heart disease in humans (OR 1.015, 95% CI 1.010–1.019).
HumansMendelian randomization
High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study · Iranian journal of medical sciences · 1 Aug 2026

Ischemic heart disease →

Angina

upin humans1OR 1.012

1 study