TERT
Gene6 papers5 findingsHGNC 11730NCBI Gene 7015Taxon 9606
- Humans1
- Animals2
- Model organisms1
Interventions
1Naringin
upin rats1Very low certainty
1 study
Naringin
upin rats1Very low certainty
Naringin increases TERT in rats.
Animalsorchidectomyoral gavage8 weeksmales
Naringin attenuates orchidectomy-induced bone loss in male rats: evidence from bone remodeling and telomere-related indices · Journal of molecular histology · 10 Sep 2026
Effects
2Alzheimer's disease
downin reviews1
1 study
Alzheimer's disease
downin reviews1
TERT protects against Alzheimer's disease.
Reviewin neurodegenerative disorders
Telomerase reverse transcriptase as a core regulator of brain health · Trends in molecular medicine · 11 Sep 2026
Multiple aging phenotypes
downin reviews1
1 study
Multiple aging phenotypes
downin reviews1
TERT decreases multiple aging phenotypes.
Reviewduring aging and neurodegeneration
Telomerase reverse transcriptase as a core regulator of brain health · Trends in molecular medicine · 11 Sep 2026
Associations
2Chronic insomnia
upin humans1
1 study
Chronic insomnia
upin humans1
Chronic insomnia is associated with TERT in humans.
Humansin patients with bipolar disorder
Clinical and Biological Characterization of Bipolar Disorder Patients With Chronic Insomnia Reveals Cortisol Reductions, Elevated TNF-α, and Increased Genetic Risk for Accelerated Aging · Bipolar disorders · 21 Sep 2026
Cancer
upin humans1
1 study
Cancer
upin humans1
TERT raises the risk of cancer in humans.
Reviewin healthy individuals
How telomere attrition protects against cancer · Nature reviews. Genetics · 1 Sep 2026
Funding
National Cancer InstituteUS$445.8kNational Institute on AgingUS$100.8k2 grants since 2025
Characterizing cancer susceptibility mechanisms for TERT/CLPTM1L and other telomere-related regions
National Cancer InstituteUniversity of ChicagoUS$445.8k2025–2030
Impact and therapeutic effects of selective TERT activation in Alzheimers disease
National Institute on AgingUniversity of Tx Md Anderson Can CtrUS$100.8k2026–2031