Atherosclerotic cardiovascular disease

1. Sleep protects against atherosclerotic cardiovascular disease in humans.

   Humans13 yearsn = 468,266

   Risk factors for atherosclerosis diverge across vascular beds · American journal of preventive cardiology · 19 Jun 2026

Sleep →

1. Physical activity protects against atherosclerotic cardiovascular disease in humans.

   Humans13 yearsn = 468,266

   Risk factors for atherosclerosis diverge across vascular beds · American journal of preventive cardiology · 19 Jun 2026

Physical activity →

1. LDL-C raises the risk of atherosclerotic cardiovascular disease in humans (sHR 1.69, 95% CI 1.35-2.12).

   Humans22.7 yearsn = 10,550

   Martin-Hopkins LDL equation best predicts cardiovascular risk · Circulation. Population health and outcomes · 30 Sep 2026

2. LDL-C lowers the risk of atherosclerotic cardiovascular disease in humans.

   Reviewin ASCVD

   Optimal LDL-C Levels for Ischemic Stroke Prevention: A Neurologist's Perspective · Journal of lipid and atherosclerosis · 27 May 2026

LDL-C →

1. Cortisol predicts atherosclerotic cardiovascular disease in humans (AUC 0.820, 95% CI 0.781-0.860).

   Humansnonfunctioning adrenal adenomas with post-DST cortisol <= 1.8 ug/dL

   Association of Post-Dexamethasone Cortisol With Cardiovascular and Metabolic Comorbidities in Patients With Nonfunctioning Adrenal Adenomas · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 1 Oct 2026

2. Cortisol is associated with atherosclerotic cardiovascular disease in humans (aOR 1.21, 95% CI 1.09-1.34).

   Humansnonfunctioning adrenal adenomas with post-DST cortisol <= 1.8 ug/dLper 0.1 ug/dL increase

   Association of Post-Dexamethasone Cortisol With Cardiovascular and Metabolic Comorbidities in Patients With Nonfunctioning Adrenal Adenomas · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 1 Oct 2026

Cortisol →

1. non-HDL cholesterol predicts atherosclerotic cardiovascular disease in humans.

   Reviewin large meta-analyses

   Non-HDL Cholesterol as a Predictor of Coronary Atherosclerosis in South Asians: A Narrative Review · Current atherosclerosis reports · 30 Sep 2026

2. non-HDL cholesterol is associated with atherosclerotic cardiovascular disease in humans.

   Reviewin South Asians

   Non-HDL Cholesterol as a Predictor of Coronary Atherosclerosis in South Asians: A Narrative Review · Current atherosclerosis reports · 30 Sep 2026

non-HDL cholesterol →

1. Polygenic risk score predicts atherosclerotic cardiovascular disease in humans (4.9-fold higher incidence).

   Humansatherosclerotic cardiovascular disease

   Genetic scores add more predictive power at lower clinical risk · medRxiv · 27 Sep 2026 · Preprint

Polygenic risk score →

1. Small dense low-density lipoprotein cholesterol raises the risk of atherosclerotic cardiovascular disease in humans (HR 1.25 (1.20-1.31) for Q4).

   Humansadjusted for covariates

   Estimated sdLDL-C predicts cardiovascular risk in Japanese adults · Journal of clinical lipidology · 15 Sep 2026

Small dense low-density lipoprotein cholesterol →

1. Hepatic fibrosis predicts atherosclerotic cardiovascular disease in humans.

   Reviewin MASLD

   Fibrosis-Driven Cardiovascular Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease: Emerging Links With Atherosclerotic Cardiovascular Disease · Cureus · 31 Aug 2026