Western-style diet

1. Western-style diet induces colonic neoplasia in mice.

   “prolonged feeding of WDs to mice produced single-crypt dysplastic lesions and focal hyperplasias indicative of tumorigenesis.”

   Animalscolonprolonged

   Apoptosis, cell replication, and Western-style diet-induced tumorigenesis in mouse colon

   Cancer research·1 Nov 1996

More on Colonic neoplasia

1. Western-style diet activates apoptosis in mice.

   “This was accompanied by diffuse activation of apoptosis of the colonic epithelial cells.”

   Animalscolon

   Apoptosis, cell replication, and Western-style diet-induced tumorigenesis in mouse colon

   Cancer research·1 Nov 1996

More on Apoptosis

1. Western-style diet increases cell cycle regulation in mice.

   “A significant and transient increase of mitotic activity in the basal and intermediate portions of the colonic crypts was seen in young mice after feeding them the WDs.”

   Animalscolonic crypts

   Apoptosis, cell replication, and Western-style diet-induced tumorigenesis in mouse colon

   Cancer research·1 Nov 1996

More on Cell cycle regulation

1. Western-style diet induces gross colonic lesions in mice.

   “feeding Western-style diets (WDs) to mice for a duration of two years without any chemical carcinogen led to the development of gross colonic lesions”

   Animalscolontwo years

   Apoptosis, cell replication, and Western-style diet-induced tumorigenesis in mouse colon

   Cancer research·1 Nov 1996